{"id":1020364,"date":"2026-11-12T10:09:34","date_gmt":"2026-11-12T15:09:34","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/"},"modified":"2026-11-12T10:09:34","modified_gmt":"2026-11-12T15:09:34","slug":"randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/","title":{"rendered":"Randomized Study of Non-Invasive Autonomic Neuromodulation for Long COVID Published Online in Neuromodulation"},"content":{"rendered":"

\nRandomized, open-label, hypothesis-generating study (541 participants enrolled; 250 met final analysis criteria) evaluated two proprietary non-invasive neuromodulation technologies, electroCore\u2019s cervical vagus nerve stimulation and Sonocea Sonic Augmentation Technology\u2122 (SAT)
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ROCKAWAY, N.J., Nov. 12, 2026 (GLOBE NEWSWIRE) — electroCore, Inc. (Nasdaq: ECOR) (\u201celectroCore\u201d or the \u201cCompany\u201d), a bioelectronic technology company, today announced that results from a randomized, open label-controlled study evaluating non-invasive autonomic neuromodulation in adults with Long COVID have been published online in\u00a0Neuromodulation: Technology at the Neural Interface<\/em>.<\/p>\n

The study, \u201cNon-invasive Autonomic Regulatory Interventions for Long COVID: A Randomized Controlled Trial,\u201d evaluated two non-invasive approaches designed to influence autonomic regulation: transcutaneous cervical vagus nerve stimulation (tcVNS) using proprietary electroCore technology and Sonocea Sonic Augmentation Technology\u2122, a proprietary acoustic neuromodulation technology. The study evaluated each intervention independently as well as the combination of the two approaches.<\/p>\n

\n Long COVID Represents a Major Unmet Medical Need<\/strong>\n <\/p>\n

Long COVID has emerged as one of the most consequential chronic health challenges resulting from the COVID-19 pandemic. A 2024 review published in Nature Medicine<\/em>1<\/sup> estimated that approximately 400 million people worldwide have experienced Long COVID, highlighting the extraordinary scale of this persistent global health problem.<\/p>\n

The condition can persist for months or years and may involve multiple organ systems, with patients reporting fatigue, cognitive dysfunction or \u201cbrain fog,\u201d sleep disturbance, shortness of breath, pain, cardiovascular symptoms, anxiety, post-traumatic stress symptoms, and autonomic dysfunction. In the United States, millions of adults continue to report Long COVID, and a substantial proportion of affected individuals report limitations in their daily activities.<\/p>\n

The burden extends well beyond individual patients. Long COVID has been associated with impaired ability to work, increased healthcare utilization, reduced quality of life, and substantial economic losses. The same Nature Medicine<\/em> review estimated the annual global economic impact as approaching approximately $1 trillion, while a separate U.S. economic analysis estimated the total societal cost of Long COVID in the United States at approximately $3.7 trillion,2<\/sup> reflecting reduced quality of life, lost earnings, and increased medical spending.<\/p>\n

Despite the enormous number of people affected and extensive research efforts, treatment options remain limited. There is currently no FDA-approved therapy specifically for Long COVID as a condition, and clinical management remains largely directed toward individual symptoms and associated conditions. This substantial unmet need underscores the importance of investigating new therapeutic approaches capable of addressing the complex, multisystem nature of Long COVID.<\/p>\n

\n Randomized Study of Autonomic Neuromodulation<\/strong>\n <\/p>\n

The four-arm randomized study enrolled 541 participants, 250 of whom met the final analytic criteria (complete outcome data and, for active-intervention participants, at least 50% adherence). It compared electroCore\u2019s cervical non-invasive vagus nerve stimulation (tcVNS), SAT, combined tcVNS plus SAT, and a monitoring-only control over four weeks. SAT was delivered through headphones using a smartphone-based protocol for 15 minutes twice daily; tcVNS consisted of two 2-minute stimulations twice daily.<\/p>\n

Across the study, the active intervention groups demonstrated improvements across multiple Long COVID symptom domains compared with monitoring alone. Improvements were observed in measures encompassing fatigue, breathing, cognition, sleep, mental health, circulation and the impact of symptoms on daily life.<\/p>\n

Depressive symptom scores decreased by approximately 33% with electroCore\u2019s cervical non-invasive vagus nerve stimulation, 31% with Sonocea\u2019s Sonic Augmentation Technology, and 34% with the combination, compared with approximately 2% in the monitoring-only control group; each active intervention demonstrated a statistically significant within-group improvement (p < 0.001) and the change over time differed significantly across the four study groups. The combined intervention was associated with an approximately 39% reduction in PTSD-related symptom scores, compared with an increase of approximately 6% in the monitoring-only group. However, direct comparisons among the three active intervention groups did not show statistically significant differences, including on PTSD-related symptoms, and the study does not establish superiority of the combined intervention.<\/p>\n

Improvements were also observed in fatigue, cognitive symptoms, breathing, and other measures of Long COVID symptom burden.<\/p>\n

These results come from an open-label study without a sham control and are considered hypothesis-generating; key limitations are described below.<\/p>\n

\u201cLong COVID represents an enormous unmet medical need,\u201d said Peter S. Staats, M.D., MBA, Chief Medical Officer and Co-Founder of electroCore and lead author of the study. \u201cMillions of people continue to experience symptoms that can affect multiple aspects of their health and their ability to work and function, yet we still have no FDA-approved therapy specifically for Long COVID as a condition. That makes the search for new therapeutic approaches particularly important.<\/p>\n

What makes these findings especially interesting is that we evaluated two distinct, non-pharmacologic approaches to autonomic neuromodulation\u2014direct cervical non-invasive vagus nerve stimulation and a novel acoustic intervention\u2014and observed improvements across multiple symptom domains. Long COVID is unlikely to have a single cause or a single solution, but these results suggest that autonomic regulation may represent a potential therapeutic target worthy of further investigation in larger, sham-controlled studies.\u201d<\/p>\n

The study was conducted remotely in adults with symptoms persisting at least three months following COVID-19 infection. Participants were randomized to monitoring alone, SAT, cervical tcVNS, or combined SAT and tcVNS. The primary endpoint was change in domains from the Symptom Burden Questionnaire for Long COVID (SBQ-LC), with additional validated, self-reported measures assessing anxiety, depression, post-traumatic stress symptoms, autonomic symptoms, and self-reported biobehavioral state.<\/p>\n

The investigators noted several limitations, including the open-label design, absence of a sham-stimulation control, reliance primarily on patient-reported outcomes, the absence of objective physiological measures of autonomic function, the facts that participants\u2019 treatment expectations were not assessed, participant attrition, and the absence of correction for multiple comparisons. Accordingly, the findings are considered hypothesis-generating and warrant confirmation in future sham-controlled studies incorporating objective physiological measures and longer follow-up.<\/p>\n

The study was funded by the Defense Threat Reduction Agency (DTRA) of the U.S. Department of Defense, which had no role in data analysis, interpretation, manuscript preparation or the decision to publish the study results. The views expressed in this release are those of the authors and the Company and do not necessarily reflect the official policy or position of the Department of Defense or the U.S. Government, and no endorsement should be inferred. Participant monitoring, randomization, data collection and database management were conducted by Leidos, an independent third party. Dr. Staats is a co-founder and Chief Medical Officer of electroCore, and co-author Stephen W. Porges, Ph.D., is a founder of Sonocea.<\/p>\n

\n A Potential New Therapeutic Direction<\/strong>\n <\/p>\n

Long COVID is increasingly understood as a heterogeneous, multisystem condition that may involve interacting immune, inflammatory, vascular, metabolic, neurological and autonomic mechanisms. This complexity may help explain why finding a single effective pharmacologic treatment has proven difficult.<\/p>\n

The authors hypothesized that interventions capable of influencing autonomic regulation through different pathways could provide another approach to addressing the broad symptom burden experienced by some patients. Cervical non-invasive vagus nerve stimulation is intended to engage the vagus nerve in the neck, while SAT uses patterned auditory stimulation intended to influence central neural networks involved in autonomic regulation.<\/p>\n

The observation that both approaches were associated with improvements provides support for further investigation of autonomic neuromodulation as an investigational, non-pharmacologic therapeutic strategy for Long COVID.<\/p>\n

Neither electroCore\u2019s cervical non-invasive vagus nerve stimulation nor Sonocea Sonic Augmentation Technology (SAT) has been cleared or approved by the FDA for the treatment of Long COVID. The safety and effectiveness of the technologies for Long COVID have not been established.<\/p>\n

\n About electroCore, Inc.<\/strong>
\n
electroCore, Inc. is a bioelectronic technology company whose mission is to improve health and quality of life through innovative non-invasive bioelectronic technologies. The Company\u2019s two leading prescription products, gammaCore\u00ae non-invasive vagus nerve stimulation (nVNS) and Quell\u00ae neurostimulator, treat chronic pain syndromes through non-invasive neuromodulation technology. Additionally, the company commercializes its handheld, and personal use Truvaga\u2122 and TAC-STIM\u2122 nVNS products utilizing bioelectronic technologies to promote general wellness and human performance. Truvaga\u2122 and TAC-STIM\u2122 are not intended to diagnose, treat, cure, mitigate or prevent any disease or condition, including Long COVID.<\/p>\n

For more information, visit www.electrocore.com<\/a>.<\/p>\n

\n About Sonocea Inc.<\/strong>
\n
Sonocea Inc. is a neuroscience technology company developing non-invasive acoustic neuromodulation approaches to support autonomic nervous system regulation. Its proprietary Sonic Augmentation Technology\u2122 (SAT) uses a novel signal-generation architecture to create structured acoustic interventions delivered through ordinary headphones or speakers.<\/p>\n

\n References<\/strong>
\n
Cutler DM. The Costs of Long COVID. JAMA Health Forum.<\/em> 2022;3(5):e221809. doi:10.1001\/jamahealthforum.2022.1809<\/p>\n

Al-Aly Z, Davis H, McCorkell L, et al. Long COVID science, research and policy. Nature Medicine.<\/em> 2024;30:2148\u20132164. doi:10.1038\/s41591-024-03173-6<\/p>\n

Staats PS, Dana AN, Lawrence T, Porges SW. Non-invasive autonomic regulatory interventions for Long COVID: a randomized controlled trial. Neuromodulation: Technology at the Neural Interface.<\/em> 2026. doi: 10.1016\/j.neurom.2026.09.025<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>\n <\/p>\n

This press release and other written and oral statements made by representatives of electroCore may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements regarding the potential implications of the study described in the release and of future research involving non-invasive vagus nerve stimulation or acoustic neuromodulation for Long COVID; the possible design, conduct or results of any future studies; the possible development, regulatory review or commercialization of technologies or products for Long COVID and other indications; the Company\u2019s future business strategies, growth opportunities, prospects, product development and market expansion; and other statements that are not historical in nature, particularly those using terms such as \u201canticipates,\u201d \u201cwill,\u201d \u201cexpects,\u201d \u201cbelieves,\u201d \u201cintends,\u201d \u201cmay,\u201d \u201cpotential\u201d and similar expressions.<\/p>\n

Actual results could differ materially from those projected in any forward-looking statement because of numerous factors, including the preliminary, hypothesis-generating nature of the findings described in this release; the open-label design of the study, the absence of a sham-stimulation control, the absence of objective physiological measures, reliance primarily on patient-reported outcomes, participant attrition and the absence of correction for multiple comparisons; the risk that future studies may not confirm these findings; the need for additional analysis and replication; uncertainties inherent in developing new products, technologies, or indications; the Company\u2019s ability to obtain any required regulatory clearances or approvals for new products, including for Long COVID; the Company\u2019s dependence on third parties, including Sonocea, for technologies evaluated in the study; the ability to commercialize products; the performance, adoption and market acceptance of non-invasive vagus nerve stimulation products; electroCore\u2019s results of operations and financial performance; inflation and currency fluctuations; competition in the industry; and overall economic and market conditions.<\/p>\n

Forward-looking statements speak only as of the date of this press release. electroCore assumes no obligation to update any forward-looking statement or the reasons actual results could differ from those projected, except as required by law. Investors should review the information in this release together with the risk-factor disclosures in electroCore\u2019s reports and other documents filed with the U.S. Securities and Exchange Commission at www.sec.gov<\/u><\/strong><\/a>.<\/p>\n

\n Contact:<\/strong>
\n
ECOR Investor Relations
(973) 302-9253
investors@electrocore.com<\/p>\n

\n

\n 1<\/sup> Al-Aly Z, Davis H, McCorkell L, et al. Long COVID science, research and policy. Nature Medicine. 2024;30:2148\u20132164. doi:10.1038\/s41591-024-03173-6.
2<\/sup> Cutler DM. The economic cost of Long COVID: An update. Harvard University. 2022. https:\/\/scholar.harvard.edu\/files\/cutler\/files\/long_covid_update_7-22.pdf\u00a0<\/p>\n

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Randomized, open-label, hypothesis-generating study (541 participants enrolled; 250 met final analysis criteria) evaluated two proprietary non-invasive neuromodulation technologies, electroCore\u2019s cervical vagus nerve stimulation and Sonocea Sonic Augmentation Technology\u2122 (SAT) ROCKAWAY, N.J., Nov. 12, 2026 (GLOBE NEWSWIRE) — electroCore, Inc. (Nasdaq: ECOR) (\u201celectroCore\u201d or the \u201cCompany\u201d), a bioelectronic technology company, today announced that results from a randomized, open label-controlled study evaluating non-invasive autonomic neuromodulation in adults with Long COVID have been published online in\u00a0Neuromodulation: Technology at the Neural Interface. The study, \u201cNon-invasive Autonomic Regulatory Interventions for Long COVID: A Randomized Controlled Trial,\u201d evaluated two non-invasive approaches designed to influence autonomic regulation: transcutaneous cervical vagus nerve stimulation (tcVNS) using proprietary electroCore technology and Sonocea Sonic Augmentation Technology\u2122, a proprietary acoustic neuromodulation technology. … <\/p>\n

Continue reading “Randomized Study of Non-Invasive Autonomic Neuromodulation for Long COVID Published Online in Neuromodulation”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1020364","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nRandomized Study of Non-Invasive Autonomic Neuromodulation for Long COVID Published Online in Neuromodulation - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Randomized Study of Non-Invasive Autonomic Neuromodulation for Long COVID Published Online in Neuromodulation - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Randomized, open-label, hypothesis-generating study (541 participants enrolled; 250 met final analysis criteria) evaluated two proprietary non-invasive neuromodulation technologies, electroCore\u2019s cervical vagus nerve stimulation and Sonocea Sonic Augmentation Technology\u2122 (SAT) ROCKAWAY, N.J., Nov. 12, 2026 (GLOBE NEWSWIRE) — electroCore, Inc. (Nasdaq: ECOR) (\u201celectroCore\u201d or the \u201cCompany\u201d), a bioelectronic technology company, today announced that results from a randomized, open label-controlled study evaluating non-invasive autonomic neuromodulation in adults with Long COVID have been published online in\u00a0Neuromodulation: Technology at the Neural Interface. 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/","og_locale":"en_US","og_type":"article","og_title":"Randomized Study of Non-Invasive Autonomic Neuromodulation for Long COVID Published Online in Neuromodulation - Market Newsdesk","og_description":"Randomized, open-label, hypothesis-generating study (541 participants enrolled; 250 met final analysis criteria) evaluated two proprietary non-invasive neuromodulation technologies, electroCore\u2019s cervical vagus nerve stimulation and Sonocea Sonic Augmentation Technology\u2122 (SAT) ROCKAWAY, N.J., Nov. 12, 2026 (GLOBE NEWSWIRE) — electroCore, Inc. (Nasdaq: ECOR) (\u201celectroCore\u201d or the \u201cCompany\u201d), a bioelectronic technology company, today announced that results from a randomized, open label-controlled study evaluating non-invasive autonomic neuromodulation in adults with Long COVID have been published online in\u00a0Neuromodulation: Technology at the Neural Interface. The study, \u201cNon-invasive Autonomic Regulatory Interventions for Long COVID: A Randomized Controlled Trial,\u201d evaluated two non-invasive approaches designed to influence autonomic regulation: transcutaneous cervical vagus nerve stimulation (tcVNS) using proprietary electroCore technology and Sonocea Sonic Augmentation Technology\u2122, a proprietary acoustic neuromodulation technology. … Continue reading \"Randomized Study of Non-Invasive Autonomic Neuromodulation for Long COVID Published Online in Neuromodulation\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/","og_site_name":"Market Newsdesk","article_published_time":"2026-11-12T15:09:34+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTg3NjA3OSM3OTYxNjQyIzIwOTg3NDQ=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"9 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Randomized Study of Non-Invasive Autonomic Neuromodulation for Long COVID Published Online in Neuromodulation","datePublished":"2026-11-12T15:09:34+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/"},"wordCount":1834,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTg3NjA3OSM3OTYxNjQyIzIwOTg3NDQ=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/randomized-study-of-non-invasive-autonomic-neuromodulation-for-long-covid-published-online-in-neuromodulation\/","name":"Randomized Study of Non-Invasive Autonomic Neuromodulation for Long COVID Published Online in Neuromodulation - 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