{"id":1020284,"date":"2026-11-12T09:29:21","date_gmt":"2026-11-12T14:29:21","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/immuneering-to-collaborate-with-astellas-on-clinical-studies-of-investigational-cldn18-2-programs-in-combination-with-atebimetinib-for-pancreatic-cancer-patients\/"},"modified":"2026-11-12T09:29:21","modified_gmt":"2026-11-12T14:29:21","slug":"immuneering-to-collaborate-with-astellas-on-clinical-studies-of-investigational-cldn18-2-programs-in-combination-with-atebimetinib-for-pancreatic-cancer-patients","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/immuneering-to-collaborate-with-astellas-on-clinical-studies-of-investigational-cldn18-2-programs-in-combination-with-atebimetinib-for-pancreatic-cancer-patients\/","title":{"rendered":"Immuneering to Collaborate with Astellas on Clinical Studies of Investigational CLDN18.2 Programs in Combination with Atebimetinib for Pancreatic Cancer Patients"},"content":{"rendered":"
\n

\n \u00a0– Collaboration aligns with Immuneering\u2019s expanding strategy to provide a broad population of cancer patients with a wide set of treatment options – <\/em>\n <\/p>\n

\n – Represents Immuneering\u2019s fourth agreement with a pharma partner –<\/em>\n <\/p>\n

\n – Further expands external partnerships to bring innovative new combinations to patients – <\/em>
\n \n <\/p>\n

NEW YORK, Nov. 12, 2026 (GLOBE NEWSWIRE) — Immuneering Corporation (Nasdaq: IMRX) today announced it has entered into a clinical trial collaboration and supply agreement with Astellas Pharma Global Development, Inc., a subsidiary of Astellas Pharma Inc. (TSE: 4503). Under the agreement, Immuneering will supply its investigational MEK inhibitor, atebimetinib, for two Astellas-sponsored studies targeting the subset of pancreatic cancer patients whose tumors express CLDN18.2. One trial will evaluate an Astellas investigational CLDN18.2-targeted program added to atebimetinib plus modified gemcitabine\/nab-paclitaxel (mGnP) in first-line metastatic pancreatic cancer patients. A second trial will evaluate a chemotherapy-free regimen combining a different Astellas investigational CLDN18.2-targeted program with atebimetinib in previously-treated metastatic pancreatic cancer patients. Further trial details will be forthcoming.<\/p>\n

\u201cThis collaboration reflects our conviction that atebimetinib has the potential to become an essential backbone therapy in a broad range of combinations across MAPK-driven cancers,\u201d said Ben Zeskind, Immuneering CEO and co-founder. \u201cAtebimetinib\u2019s unique tolerability profile and broad activity make it well suited to combine with a wide range of innovative medicines targeted to specific subsets of patients, including the CLDN18.2-targeted therapies that Astellas is developing.”<\/p>\n

\u201cClaudin 18.2 has emerged as a promising target in gastrointestinal cancers,\u201d said Igor Matushansky, MD, PhD, Chief Medical Officer of Immuneering. \u201cBy combining CLDN18.2 targeted therapy with atebimetinib, these studies will evaluate the extent to which there is synergy between these distinct yet complementary mechanisms that can benefit patients with CLDN18.2-expressing pancreatic cancer.\u201d<\/p>\n

Under the terms of the collaboration, Astellas will sponsor and conduct the planned studies and Immuneering will supply atebimetinib. Immuneering maintains global development and commercialization rights to atebimetinib, and Astellas maintains global development and commercialization rights to its CLDN18.2-targeted programs.<\/p>\n

\n About Immuneering Corporation<\/strong>\n <\/p>\n

Immuneering is a late-stage clinical oncology company dedicated to keeping cancer patients alive and helping them thrive, with an initial focus on patients with RAS, RAF, and other MAPK-driven cancers. The Company is developing an entirely new category of cancer medicines, Deep Cyclic Inhibitors, designed to improve overall survival by three mechanisms: shrinking tumors durably with less resistance, preserving body mass by countering cachexia, and minimizing side effects to maximize performance status and combinability. Immuneering\u2019s lead product candidate, atebimetinib, is an oral, once-daily Deep Cyclic Inhibitor of MEK, designed to improve survival across many cancer indications. The Company is conducting a global randomized pivotal trial, MAPKeeper 301, evaluating atebimetinib in combination with chemotherapy in first-line pancreatic cancer patients. The Company\u2019s development pipeline also includes additional combination opportunities and preclinical stage programs. For more information, please visit www.immuneering.com.<\/p>\n

\n Forward-Looking Statements<\/strong>\n <\/p>\n

This press release contains forward-looking statements, including within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, statements regarding: the treatment potential of atebimetinib, alone or in combination with other agents to treat cancer including modified Gemcitabine\/nab-paclitaxel (mGnP), claudin 18.2 targeted agents and other Astellas compounds, the suitability of combining atebimetinib, and its potential to reduce tumor volume and preserve body mass in pancreatic cancer; the timing the timing and number of studies being planned and evaluated under this collaboration; and the potential ability of the three design mechanisms of atebimetinib to shrink tumors durably, improve overall survival and overcome the limitations of conventional MAPK inhibition and provide a more sustained clinical benefit for patients.<\/p>\n

These forward-looking statements are based on management\u2019s current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: we are a late-stage clinical oncology company with a limited operating history and have not completed any registrational clinical trials; we have incurred significant losses, are not currently profitable and may never become profitable; limitations on our cash runway and potential increases in expenditures; our need for additional funding; our unproven approach to therapeutic intervention; our ability to address regulatory questions and changing regulatory standards, and the uncertainties relating to regulatory filings, reviews and approvals; the lengthy, expensive, and uncertain process of clinical drug development, including the uncertainty of whether positive preclinical or early clinical efficacy and safety results are confirmed in later-stage trials, potential delays in activation of trial sites or enrollment of trial participants, or failure to obtain regulatory approvals; our reliance on third parties and collaborators to conduct our clinical trials, manufacture our product candidates, and develop and commercialize our product candidates, if approved; failure to compete successfully against other drug companies; protection of our proprietary technology and the confidentiality of our trade secrets; potential lawsuits for, or claims of, infringement of third-party intellectual property or challenges to the ownership of our intellectual property; our patents being found invalid or unenforceable; costs and resources of operating as a public company; and unfavorable or no analyst research or reports.<\/p>\n

These and other important factors discussed under the caption \u201cRisk Factors\u201d in our Quarterly Report on Form 10-Q for the period ended September 30, 2026, and our other reports filed with the U.S. Securities and Exchange Commission, could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, except as required by law, we disclaim any obligation to do so, even if subsequent events cause our views to change. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.<\/p>\n

\n Investor Contact<\/strong>:
Laurence Watts
New Street Investor Relations
laurence@newstreetir.com<\/p>\n

\n Media Contact<\/strong>:
David Caouette
dcaouette@immuneering.com<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

\u00a0– Collaboration aligns with Immuneering\u2019s expanding strategy to provide a broad population of cancer patients with a wide set of treatment options – – Represents Immuneering\u2019s fourth agreement with a pharma partner – – Further expands external partnerships to bring innovative new combinations to patients – NEW YORK, Nov. 12, 2026 (GLOBE NEWSWIRE) — Immuneering Corporation (Nasdaq: IMRX) today announced it has entered into a clinical trial collaboration and supply agreement with Astellas Pharma Global Development, Inc., a subsidiary of Astellas Pharma Inc. (TSE: 4503). Under the agreement, Immuneering will supply its investigational MEK inhibitor, atebimetinib, for two Astellas-sponsored studies targeting the subset of pancreatic cancer patients whose tumors express CLDN18.2. One trial will evaluate an Astellas investigational CLDN18.2-targeted program … <\/p>\n

Continue reading “Immuneering to Collaborate with Astellas on Clinical Studies of Investigational CLDN18.2 Programs in Combination with Atebimetinib for Pancreatic Cancer Patients”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1020284","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nImmuneering to Collaborate with Astellas on Clinical Studies of Investigational CLDN18.2 Programs in Combination with Atebimetinib for Pancreatic Cancer Patients - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/immuneering-to-collaborate-with-astellas-on-clinical-studies-of-investigational-cldn18-2-programs-in-combination-with-atebimetinib-for-pancreatic-cancer-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immuneering to Collaborate with Astellas on Clinical Studies of Investigational CLDN18.2 Programs in Combination with Atebimetinib for Pancreatic Cancer Patients - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"\u00a0– Collaboration aligns with Immuneering\u2019s expanding strategy to provide a broad population of cancer patients with a wide set of treatment options – – Represents Immuneering\u2019s fourth agreement with a pharma partner – – Further expands external partnerships to bring innovative new combinations to patients – NEW YORK, Nov. 12, 2026 (GLOBE NEWSWIRE) — Immuneering Corporation (Nasdaq: IMRX) today announced it has entered into a clinical trial collaboration and supply agreement with Astellas Pharma Global Development, Inc., a subsidiary of Astellas Pharma Inc. (TSE: 4503). Under the agreement, Immuneering will supply its investigational MEK inhibitor, atebimetinib, for two Astellas-sponsored studies targeting the subset of pancreatic cancer patients whose tumors express CLDN18.2. 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(TSE: 4503). Under the agreement, Immuneering will supply its investigational MEK inhibitor, atebimetinib, for two Astellas-sponsored studies targeting the subset of pancreatic cancer patients whose tumors express CLDN18.2. 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