{"id":1020000,"date":"2026-11-11T11:01:16","date_gmt":"2026-11-11T16:01:16","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/guardant-health-introduces-new-epigenomic-applications-providing-deeper-insights-for-treatment-selection-with-guardant360-liquid\/"},"modified":"2026-11-11T11:01:16","modified_gmt":"2026-11-11T16:01:16","slug":"guardant-health-introduces-new-epigenomic-applications-providing-deeper-insights-for-treatment-selection-with-guardant360-liquid","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/guardant-health-introduces-new-epigenomic-applications-providing-deeper-insights-for-treatment-selection-with-guardant360-liquid\/","title":{"rendered":"Guardant Health Introduces New Epigenomic Applications Providing Deeper Insights for Treatment Selection with Guardant360\u00ae Liquid"},"content":{"rendered":"<p>        <!--.bwlistdisc { list-style-type: disc }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p><b>Guardant Health Introduces New Epigenomic Applications Providing Deeper Insights for Treatment Selection with Guardant360<sup>\u00ae<\/sup> Liquid<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li><i>Powered by InfinityAI, expanded capabilities bring together genomics and epigenomics to inform therapy selection in breast and lung cancers and identify additional treatment opportunities<\/i><\/li>\n<\/ul>\n<p>PALO ALTO, Calif.&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nGuardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced new applications for Guardant360<sup>\u00ae<\/sup> Liquid designed to help oncologists understand how a patient\u2019s cancer may respond to treatment in the absence of traditional biomarkers.<\/p>\n<p>\nThe expanded capabilities include five key advances: Two novel epigenomic predictors identify patients that may benefit from selective estrogen receptor degraders (SERDs) in advanced breast cancer and immune checkpoint inhibitor (ICI) monotherapy in advanced non-small cell lung cancer (NSCLC). Complementing ICI monotherapy selection in NSCLC, Guardant360 Liquid will also include epigenomic identification of patients who are PD-L1 negative without requiring a tissue sample. Additionally, epigenomic features now identify 20-45% of <i>ALK <\/i>fusions and over 250% more <i>MTAP <\/i>deletions missed by genomic liquid testing alone. Together, these multimodal offerings aim to address treatment questions that genomic biomarkers alone may leave unanswered.<\/p>\n<p>\nThe applications are powered by InfinityAI, the smart platform behind Guardant\u2019s next-generation cancer tests. As the only platform with genome-wide methylation coverage, Guardant can uncover more signals of tumor biology that may help physicians assess treatment options.<\/p>\n<p>\n\u201cBy bringing genomics, epigenomics and AI together, Guardant is trailblazing a new standard of oncology care,\u201d said Helmy Eltoukhy, Guardant Health chairman and co-CEO. \u201cOur goal is to translate deeper biological insights into practical information that gives physicians greater confidence in treatment decisions and brings us toward the fulfillment of what precision medicine can be.\u201d<\/p>\n<p>\nThe expanded applications address key clinical needs:<\/p>\n<ul class=\"bwlistdisc\">\n<li><b>Informing SERD treatment decisions in breast cancer <\/b>to help identify patients with hormone receptor-positive, HER2-negative breast cancer progressing on first-line therapy whose tumors may benefit from SERD therapy, including those without an <i>ESR1<\/i> mutation. The application will provide insight into endocrine therapy sensitivity in a population where mutation testing alone may not identify all who could benefit.\n<\/li>\n<li><b>Assessing immunotherapy response in advanced lung cancer<\/b> to uncover the likelihood of benefit from ICI monotherapy vs. chemoimmunotherapy in advanced NSCLC by combining epigenomic tumor microenvironment characterization with tumor mutational burden (TMB) and microsatellite instability.\n<\/li>\n<li><b>Identifying additional <i>ALK<\/i> fusions by methylation <\/b>to reveal treatable drivers of a patient\u2019s cancer and potentially increase progression-free survival if the appropriate treatment is selected.\n<\/li>\n<li><b>Enabling blood-based assessment of PD-L1 status <\/b>to help identify patients with NSCLC who may benefit from chemotherapy in addition to immunotherapy.\n<\/li>\n<li><b>Evaluating new targeted approaches regarding <i>MTAP <\/i>deletion<\/b>, including the use of PRMT5 and MAT2A inhibitors, to help inform clinical trial enrollment in advanced lung cancer.\n<\/li>\n<\/ul>\n<p>\nBy incorporating advanced insights across genomics and epigenomics, Guardant360 Liquid is designed to provide a more complete view of cancer and support increasingly individualized treatment decisions.<\/p>\n<p>\nThe expansion advances Guardant\u2019s strategy of developing new clinical applications from its oncology testing portfolio, translating discoveries into clinically relevant solutions across the cancer care continuum.<\/p>\n<p><b>About Guardant Health<\/b><\/p>\n<p>\nGuardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fguardanthealth.com%2F&amp;esheet=54639415&amp;newsitemid=20261110842878&amp;lan=en-US&amp;anchor=guardanthealth.com&amp;index=1&amp;md5=9e2b55f7a9a306908c98e70a22227e71\">guardanthealth.com<\/a> and follow the company on <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fguardanthealth&amp;esheet=54639415&amp;newsitemid=20261110842878&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=2&amp;md5=834868d2cb978b98c6575be0a6377570\">LinkedIn<\/a>, <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2FGuardantHealth&amp;esheet=54639415&amp;newsitemid=20261110842878&amp;lan=en-US&amp;anchor=X+%28Twitter%29&amp;index=3&amp;md5=9f7b3cc80a29e024487f9a2fb4fcea2d\">X (Twitter)<\/a> and <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.facebook.com%2Fguardanthealth&amp;esheet=54639415&amp;newsitemid=20261110842878&amp;lan=en-US&amp;anchor=Facebook&amp;index=4&amp;md5=f011bb4bedf32430e23736f21244e0ea\">Facebook<\/a>.<\/p>\n<p><b>Guardant Health Forward-Looking Statements<\/b><\/p>\n<p>\nThis press release contains forward-looking statements within the meaning of federal securities laws, including statements regarding the potential utilities, values, benefits and advantages of Guardant Health\u2019s liquid biopsy tests or assays, which involve risks and uncertainties that could cause the actual results to differ materially from the anticipated results and expectations expressed in these forward-looking statements. These statements are based on current expectations, forecasts and assumptions, and actual outcomes and results could differ materially from these statements due to a number of factors. These and additional risks and uncertainties that could affect Guardant Health\u2019s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions \u201cRisk Factors\u201d and \u201cManagement\u2019s Discussion and Analysis of Financial Condition and Results of Operation\u201d and elsewhere in its Annual Report on Form 10-K for the year ended December 31, 2025 and in its other reports filed with or furnished to the Securities and Exchange Commission. The forward-looking statements in this press release are based on information available to Guardant Health as of the date hereof, and Guardant Health disclaims any obligation to update any forward-looking statements provided to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based, except as required by law. These forward-looking statements should not be relied upon as representing Guardant Health\u2019s views as of any date subsequent to the date of this press release.<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20261110842878r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20261110842878\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20261110842878\/en\/<\/a><\/span><\/p>\n<p><b>Investor Contact:<br \/>\n<\/b><br \/>Zarak Khurshid<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:investors@guardanthealth.com\">investors@guardanthealth.com<br \/>\n<\/a><\/p>\n<p><b>Media Contact:<br \/>\n<\/b><br \/>Meaghan Smith<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:press@guardanthealth.com\">press@guardanthealth.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> California United States North America<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Technology Genetics Health Technology Other Health Biotechnology Health Science Oncology Artificial Intelligence Other Science<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20261110842878\/en\/2768869\/3\/GuardantHealthMasterLogo_ND_RGB_3x.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Guardant Health Introduces New Epigenomic Applications Providing Deeper Insights for Treatment Selection with Guardant360\u00ae Liquid Powered by InfinityAI, expanded capabilities bring together genomics and epigenomics to inform therapy selection in breast and lung cancers and identify additional treatment opportunities PALO ALTO, Calif.&#8211;(BUSINESS WIRE)&#8211; Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced new applications for Guardant360\u00ae Liquid designed to help oncologists understand how a patient\u2019s cancer may respond to treatment in the absence of traditional biomarkers. The expanded capabilities include five key advances: Two novel epigenomic predictors identify patients that may benefit from selective estrogen receptor degraders (SERDs) in advanced breast cancer and immune checkpoint inhibitor (ICI) monotherapy in advanced non-small cell lung cancer (NSCLC). Complementing ICI &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/guardant-health-introduces-new-epigenomic-applications-providing-deeper-insights-for-treatment-selection-with-guardant360-liquid\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Guardant Health Introduces New Epigenomic Applications Providing Deeper Insights for Treatment Selection with Guardant360\u00ae Liquid&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1020000","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Guardant Health Introduces New Epigenomic Applications Providing Deeper Insights for Treatment Selection with Guardant360\u00ae Liquid - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/guardant-health-introduces-new-epigenomic-applications-providing-deeper-insights-for-treatment-selection-with-guardant360-liquid\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Guardant Health Introduces New Epigenomic Applications Providing Deeper Insights for Treatment Selection with Guardant360\u00ae Liquid - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Guardant Health Introduces New Epigenomic Applications Providing Deeper Insights for Treatment Selection with Guardant360\u00ae Liquid Powered by InfinityAI, expanded capabilities bring together genomics and epigenomics to inform therapy selection in breast and lung cancers and identify additional treatment opportunities PALO ALTO, Calif.&#8211;(BUSINESS WIRE)&#8211; Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced new applications for Guardant360\u00ae Liquid designed to help oncologists understand how a patient\u2019s cancer may respond to treatment in the absence of traditional biomarkers. The expanded capabilities include five key advances: Two novel epigenomic predictors identify patients that may benefit from selective estrogen receptor degraders (SERDs) in advanced breast cancer and immune checkpoint inhibitor (ICI) monotherapy in advanced non-small cell lung cancer (NSCLC). 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(Nasdaq: GH), a leading precision oncology company, today announced new applications for Guardant360\u00ae Liquid designed to help oncologists understand how a patient\u2019s cancer may respond to treatment in the absence of traditional biomarkers. The expanded capabilities include five key advances: Two novel epigenomic predictors identify patients that may benefit from selective estrogen receptor degraders (SERDs) in advanced breast cancer and immune checkpoint inhibitor (ICI) monotherapy in advanced non-small cell lung cancer (NSCLC). 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