{"id":1018394,"date":"2026-11-06T11:03:42","date_gmt":"2026-11-06T16:03:42","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/"},"modified":"2026-11-06T11:03:42","modified_gmt":"2026-11-06T16:03:42","slug":"new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/","title":{"rendered":"New phase 2 data highlight the strength of the immune response induced by personalized cancer vaccine EVX-01"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li style=\"text-align:justify\">\n          <b>Detection of neoantigen-specific T cells directly\u00a0<\/b><br \/>\n          <b><br \/>\n            <i>ex vivo<\/i><br \/>\n          <\/b><br \/>\n          <b> indicates strong EVX-01-induced immune responses<\/b>\n        <\/li>\n<li style=\"text-align:justify\">\n          <b>Data further underlines the strong predictive performance of Evaxion\u2019s AI-Immunology\u2122 platform<\/b>\n        <\/li>\n<li style=\"text-align:justify\">\n          <b>The new biomarker data supplements recently published three-year data showing 89% vaccine target precision and sustained T-cell and clinical responses<\/b><br \/>\n          \n        <\/li>\n<\/ul>\n<p align=\"justify\">COPENHAGEN, Denmark, November 6, 2026 &#8211; Evaxion A\/S (NASDAQ: EVAX) (\u201cEvaxion\u201d), a clinical-stage TechBio company developing novel immunotherapies with its pioneering AI-Immunology\u2122 platform, announces new biomarker data from its phase 2 trial with personalized cancer vaccine EVX-01 in patients with advanced melanoma (skin cancer).<\/p>\n<p align=\"justify\">The data demonstrate potent EVX-01 induced immune responses and further underline the strong predictive performance of Evaxion\u2019s AI-Immunology\u2122 platform. It will be presented in both an oral and a poster session today and tomorrow respectively at the Society for Immunotherapy of Cancer (SITC) 2026 Annual Meeting, taking place in Phoenix, Arizona.<\/p>\n<p align=\"justify\">\u201cIt is exciting to announce yet another set of new and promising data providing insights into the magnitude, quality and systemic impact of EVX-01-induced immunity in advanced melanoma. The data provide a clear demonstration of the very strong immune responses induced by EVX-01 and also validates our AI-Immunology\u2122 platform further. We are looking forward to sharing and discussing this data with both scientific stakeholders and potential business partners at the important SITC meeting\u201d, says Birgitte R\u00f8n\u00f8, CSO and COO of Evaxion.<\/p>\n<p align=\"justify\">\n        <b>Comprehensive data package <\/b><br \/>\n        <br \/>The new data adds to EVX-01\u2019s already comprehensive data package which includes three-year clinical response and immune data presented at the European Society for Medical Oncology (ESMO) Congress 2026 held in October. These data showed 89% vaccine target precision and sustained T-cell and clinical responses at three-year follow-up in the phase 2 trial.<\/p>\n<p align=\"justify\">New findings include detection of EVX-01 induced neoantigen-specific T-cells directly <i>ex vivo<\/i>, which is a clear testament to the magnitude of the vaccine-induced immune responses. <i>Ex vivo<\/i> responses were dominated by CD4+ T-cells, while CD8+ T-cell responses were observed in half of patients. \u00a0\u00a0<\/p>\n<p align=\"justify\">The data also documents a significant association (p&lt;0.001) between predictions by AI-Immunology\u2122 and actual T-cell responses, confirming the strong predictive performance of the platform. Essentially, the platform predicts, with very high precision, which neoantigens will illicit the strongest immune responses allowing for selection of these as optimal vaccine targets.<\/p>\n<p align=\"justify\">\n        <b>SITC oral and poster presentation details:<\/b><br \/>\n        \n      <\/p>\n<ul>\n<li style=\"text-align:justify\">Abstract title: EVX-01 personalized AI-designed vaccine plus pembrolizumab induce neoantigen-specific T-cell responses and systemic immune modulation in advanced melanoma<\/li>\n<li style=\"text-align:justify\">Abstract#: 502<\/li>\n<\/ul>\n<p align=\"justify\">\n        <u>Oral presentation:<\/u><br \/>\n        \n      <\/p>\n<ul>\n<li style=\"text-align:justify\">Session: 105b: Rapid Oral &#8211; Clinical 1<\/li>\n<li style=\"text-align:justify\">Location: Phoenix Convention Center, West Building-300 Level &#8211; 301BC<\/li>\n<li style=\"text-align:justify\">Date\/Time: Friday, November 6, 2026, 12:30-1:30pm MT \/ 20.30-21.30 CET <\/li>\n<li style=\"text-align:justify\">Presenter: \u00a0Mads Lausen, Senior Scientist at Evaxion<\/li>\n<\/ul>\n<p align=\"justify\">\n        <u>Poster presentation<\/u>:<\/p>\n<ul>\n<li style=\"text-align:justify\">Session: Poster Session<\/li>\n<li style=\"text-align:justify\">Location: Phoenix Convention Center, North Building-Lower Level &#8211; Exhibition Halls 4-6<\/li>\n<li style=\"text-align:justify\">Date\/Time: Saturday, November 7, 2026, 12:30-1:30pm &amp; 6:40-8:10pm MT \/ 20:30-21:30 CET &amp; 02:40-04:10 CET (Sunday, November 8)<\/li>\n<li style=\"text-align:justify\">Presenter: Mads Lausen, Senior Scientist at Evaxion<\/li>\n<\/ul>\n<p align=\"justify\">\n        <b>About the phase 2 trial<\/b><br \/>\n        <br \/>The phase 2 trial investigated EVX-01 in patients with advanced melanoma (skin cancer). Each patient enrolled in the trial received a unique vaccine designed with Evaxion\u2019s AI-Immunology\u2122 prediction platform and manufactured based on their individual biology.<\/p>\n<p align=\"justify\">At two-year follow-up, the trial demonstrated an Objective Response Rate (ORR) of 75% as 12 out of 16 patients had objective clinical responses, with four patients obtaining a complete response. Clinical and T-cell responses were sustained at three-year follow-up. 89% of the EVX-01 neoantigen targets triggered a tumor-specific immune response in the patients.<\/p>\n<p align=\"justify\">In the first two-years, patients received EVX-01 in combination with MSD\u2019s (Merck &amp; Co., Inc., Rahway, NJ, USA) anti-PD-1 therapy, KEYTRUDA\u00ae (pembrolizumab). In the third year, a subset of patients received EVX-01 as stand-alone therapy. KEYTRUDA\u00ae is a registered trademark of Merck Sharp &amp; Dohme LLC, a subsidiary of Merck &amp; Co., Inc., Rahway, NJ, USA.<\/p>\n<p align=\"justify\">\n        <b>About EVX-01<\/b><br \/>\n        <br \/>EVX-01 is a personalized peptide-based cancer vaccine intended for first-line treatment of multiple advanced solid cancer tumors. It is currently being evaluated as a treatment of advanced melanoma and is Evaxion\u2019s lead clinical asset.<\/p>\n<p align=\"justify\">Designed with our AI-Immunology\u2122 platform, EVX-01 is tailored to target the unique tumor profile and immune characteristics of each patient. It engages the patient&#8217;s immune system by mounting a targeted response against tumor-specific neoantigens.<\/p>\n<p align=\"justify\">\n        <b>Contact information<\/b><br \/>\n        <br \/>Evaxion A\/S<br \/>Mads Kronborg<br \/>Vice President, Investor Relations &amp; Communication<br \/>+45 53 54 82 96 <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=EfNmWphMb2tubCfCnjTccQ-phQ0auxfyDhJd8WgYzbsJ38_W3y4Bablj85KdxOyIA6dXy8H-WjOWEzFZCWjfqeyph8gNLuUetQ2pBHLi8po=\" rel=\"nofollow\" target=\"_blank\">mak@evaxion.ai<\/a><\/p>\n<p align=\"justify\">\n        <b>About Evaxion<\/b><br \/>\n        <br \/>Evaxion is a pioneering clinical-stage TechBio company based upon its proprietary, clinically validated and scalable AI platform, AI-Immunology\u2122. The platform harnesses the power of artificial intelligence to decode the human immune system and develop novel immunotherapies for cancer as well as infectious and autoimmune diseases.<\/p>\n<p align=\"justify\">With AI-Immunology\u2122 we conduct rapid, efficient and high-quality target discovery, drug design and development. Our team of +40 experts covers the entire value chain from target discovery to clinical development.<\/p>\n<p align=\"justify\">We have developed a pipeline of both personalized and off-the-shelf cancer vaccine candidates as well as prophylactic vaccine candidates for infectious diseases. All our candidates address high unmet medical needs, reflecting our commitment to transforming patients\u2019 lives by providing innovative and targeted treatment options.<\/p>\n<p align=\"justify\">For more information about Evaxion, AI-Immunology\u2122 and our pipeline, please visit our <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Iu_GS6-UUnBOZpDjJcpAKcKJPKJrrIIHkndHEMUoiOB37I9PbIdh7VXIdrf3D3LhUW6JErJSb_T2NTVuUfMFAg==\" rel=\"nofollow\" target=\"_blank\">website<\/a>.\u00a0<\/p>\n<p align=\"justify\">\n        <b>Forward-looking statement<\/b>\u00a0<br \/>This\u00a0announcement contains forward-looking statements\u00a0within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended.\u00a0The words\u00a0\u201ctarget,\u201d \u201cbelieve,\u201d \u201cexpect,\u201d \u201chope,\u201d \u201caim,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cmight,\u201d \u201canticipate,\u201d \u201ccontemplate,\u201d \u201ccontinue,\u201d \u201cestimate,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cwill,\u201d \u201ccan have,\u201d \u201clikely,\u201d \u201cshould,\u201d \u201cwould,\u201d \u201ccould,\u201d and other words and terms of similar meaning\u00a0identify forward-looking statements.\u00a0Actual results may differ materially from those indicated by such forward-looking statements as a result of various factors, including, but not limited to, risks related to: our financial condition and need for additional capital; our development work; cost and success of our product development activities and preclinical and clinical trials; commercializing any approved pharmaceutical product developed using our AI platform technology, including the rate and degree of market acceptance of our product candidates; our dependence on third parties including for conduct of clinical testing and product manufacture; our inability to enter into partnerships; government regulation; protection of our intellectual property rights; employee matters and managing growth; our ADSs and ordinary shares,\u00a0the impact of international economic, political, legal, compliance, social and business factors, including inflation, and the effects on our\u00a0business from other significant geopolitical and macro-economic events;\u00a0and other uncertainties affecting our business operations and financial condition.\u00a0For a further discussion of these risks, please refer to the risk factors included in our most recent Annual Report on Form 20-F\u00a0and other filings\u00a0with the US Securities and Exchange Commission (SEC), which are available at\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=g5N5BdCB6G9N0unExL5fR3kCWk0C6cWqmrxap05S6fpO01PwNFbteGSnnaxlxFnKbkITLqlsLFgrlIVE3vfI0Slq54QlSaUVa16HaXy3v-LuQ_CA8-W2fFDV-1M0Cag6g3rw3bgqvtSXvIot7mYLcYxUUn1cDv21dKo4mR2wvdv4TrEWy8_bp42NmuYZEWQZoc0ckSxSdfnHD9_m0qP7g7xNy5l85s66IA8ibo3VLWE=\" rel=\"nofollow\" target=\"_blank\"><b>www.sec.gov<\/b><\/a>.\u00a0We do not assume any obligation to update any forward-looking statements except as required by law.\u00a0<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMTMwMjI1NCM0MDI1NTk5OTUjMjI1MjA4Nw==\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml-eu.globenewswire.com\/media\/ZDYyMDAyMGItOGU2ZC00NzhiLWEyMGItNGI5OTkwN2ZlYWFlLTEyNjM2NDAtMjAyNi0xMS0wNi1lbg==\/tiny\/Evaxion.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Detection of neoantigen-specific T cells directly\u00a0 ex vivo indicates strong EVX-01-induced immune responses Data further underlines the strong predictive performance of Evaxion\u2019s AI-Immunology\u2122 platform The new biomarker data supplements recently published three-year data showing 89% vaccine target precision and sustained T-cell and clinical responses COPENHAGEN, Denmark, November 6, 2026 &#8211; Evaxion A\/S (NASDAQ: EVAX) (\u201cEvaxion\u201d), a clinical-stage TechBio company developing novel immunotherapies with its pioneering AI-Immunology\u2122 platform, announces new biomarker data from its phase 2 trial with personalized cancer vaccine EVX-01 in patients with advanced melanoma (skin cancer). The data demonstrate potent EVX-01 induced immune responses and further underline the strong predictive performance of Evaxion\u2019s AI-Immunology\u2122 platform. It will be presented in both an oral and a poster session today &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;New phase 2 data highlight the strength of the immune response induced by personalized cancer vaccine EVX-01&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1018394","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New phase 2 data highlight the strength of the immune response induced by personalized cancer vaccine EVX-01 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New phase 2 data highlight the strength of the immune response induced by personalized cancer vaccine EVX-01 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Detection of neoantigen-specific T cells directly\u00a0 ex vivo indicates strong EVX-01-induced immune responses Data further underlines the strong predictive performance of Evaxion\u2019s AI-Immunology\u2122 platform The new biomarker data supplements recently published three-year data showing 89% vaccine target precision and sustained T-cell and clinical responses COPENHAGEN, Denmark, November 6, 2026 &#8211; Evaxion A\/S (NASDAQ: EVAX) (\u201cEvaxion\u201d), a clinical-stage TechBio company developing novel immunotherapies with its pioneering AI-Immunology\u2122 platform, announces new biomarker data from its phase 2 trial with personalized cancer vaccine EVX-01 in patients with advanced melanoma (skin cancer). The data demonstrate potent EVX-01 induced immune responses and further underline the strong predictive performance of Evaxion\u2019s AI-Immunology\u2122 platform. 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/","og_locale":"en_US","og_type":"article","og_title":"New phase 2 data highlight the strength of the immune response induced by personalized cancer vaccine EVX-01 - Market Newsdesk","og_description":"Detection of neoantigen-specific T cells directly\u00a0 ex vivo indicates strong EVX-01-induced immune responses Data further underlines the strong predictive performance of Evaxion\u2019s AI-Immunology\u2122 platform The new biomarker data supplements recently published three-year data showing 89% vaccine target precision and sustained T-cell and clinical responses COPENHAGEN, Denmark, November 6, 2026 &#8211; Evaxion A\/S (NASDAQ: EVAX) (\u201cEvaxion\u201d), a clinical-stage TechBio company developing novel immunotherapies with its pioneering AI-Immunology\u2122 platform, announces new biomarker data from its phase 2 trial with personalized cancer vaccine EVX-01 in patients with advanced melanoma (skin cancer). The data demonstrate potent EVX-01 induced immune responses and further underline the strong predictive performance of Evaxion\u2019s AI-Immunology\u2122 platform. It will be presented in both an oral and a poster session today &hellip; Continue reading \"New phase 2 data highlight the strength of the immune response induced by personalized cancer vaccine EVX-01\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/","og_site_name":"Market Newsdesk","article_published_time":"2026-11-06T16:03:42+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMTMwMjI1NCM0MDI1NTk5OTUjMjI1MjA4Nw==","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"New phase 2 data highlight the strength of the immune response induced by personalized cancer vaccine EVX-01","datePublished":"2026-11-06T16:03:42+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/"},"wordCount":1120,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMTMwMjI1NCM0MDI1NTk5OTUjMjI1MjA4Nw==","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/new-phase-2-data-highlight-the-strength-of-the-immune-response-induced-by-personalized-cancer-vaccine-evx-01\/","name":"New phase 2 data highlight the strength of the immune response induced by personalized cancer vaccine EVX-01 - 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