{"id":1014614,"date":"2026-10-28T10:28:11","date_gmt":"2026-10-28T14:28:11","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/proqr-to-present-clinical-and-preclinical-progress-from-ax-0810-and-ax-0811-at-upcoming-conferences\/"},"modified":"2026-10-28T10:28:11","modified_gmt":"2026-10-28T14:28:11","slug":"proqr-to-present-clinical-and-preclinical-progress-from-ax-0810-and-ax-0811-at-upcoming-conferences","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/proqr-to-present-clinical-and-preclinical-progress-from-ax-0810-and-ax-0811-at-upcoming-conferences\/","title":{"rendered":"ProQR to Present Clinical and Preclinical Progress from AX-0810 and AX-0811 at Upcoming Conferences"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li style=\"margin-bottom:12pt\">ProQR to present its ADAR-mediated RNA editing approach and progress toward next-generation editing oligonucleotides at TIDES Europe plenary session<\/li>\n<li style=\"margin-bottom:12pt\">AX-0810 Phase 1 data to be featured in two poster presentations at AASLD, The Liver Meeting<sup>\u00ae<\/sup> 2026, including one late-breaking poster<\/li>\n<li style=\"margin-bottom:12pt\">Cohort 3 data and the 12 week follow up from the AX-0810 Phase 1 study along with new preclinical proof-of-concept data for AX-0811 to be presented at Nature Conferences RNA at the Bench and Bedside V in December 2026<\/li>\n<li style=\"margin-bottom:12pt\">Next-generation AX-0811, an NTCP-targeting RNA editing oligonucleotide generated using ProQR\u2019s AI-enabled discovery engine is being evaluated in a Phase 1 study in healthy volunteers, with initial data expected in early January 2027<\/li>\n<\/ul>\n<p>LEIDEN, Netherlands &amp; CAMBRIDGE, Mass., Oct.  28, 2026  (GLOBE NEWSWIRE) &#8212; ProQR Therapeutics N.V. (Nasdaq: PRQR) (ProQR), a clinical-stage company dedicated to changing lives through transformative RNA therapies based on its proprietary ADAR-mediated Axiomer\u2122 RNA editing technology platform, today announced upcoming presentations highlighting clinical and preclinical progress with AX-0810 and AX-0811 and the broader Axiomer RNA editing platform at TIDES Europe, The Liver Meeting 2026, Nature Conferences RNA at the Bench and Bedside V.\u00a0<\/p>\n<p>\n        <b>Upcoming Presentations<\/b>\n      <\/p>\n<p>\n        <b>TIDES Europe 2026<\/b>\n      <\/p>\n<p>Gerard Platenburg, ProQR\u2019s chief scientific officer, will deliver a plenary presentation reviewing previously presented clinical findings from AX-0810, including a favorable safety and tolerability profile and NTCP target engagement that demonstrate successful translation. The presentation will also highlight AI-enabled advances in the discovery of AX-0811, a next-generation Axiomer RNA editing oligonucleotide with preclinical data demonstrating greater potency and durability, underscoring the potential of ProQR\u2019s Axiomer platform. <\/p>\n<p>\n        <b>Plenary session title:<\/b> \u201cClinical Validation of ADAR RNA editing and translation to AI-driven next-generation EONs\u201d<br \/><b>Presenter:<\/b> Gerard Platenburg, Chief Scientific Officer<br \/><b>Date and time:<\/b> November 3, 2026, 16:25 CET<br \/><b>Location:<\/b> Amsterdam, Netherlands <\/p>\n<p>\n        <b>AASLD The Liver Meeting<\/b><br \/>\n        <sup><br \/>\n          <b>\u00ae<\/b><br \/>\n        <\/sup><br \/>\n        <b> 2026<\/b>\n      <\/p>\n<p>The AX-0810 Phase 1 study will be featured in two poster presentations at The Liver Meeting<sup>\u00ae<\/sup> 2026, the annual meeting of the American Association for the Study of Liver Diseases (AASLD), taking place November 5\u20139, 2026. The presentations will focus on study design, as well as previously disclosed safety, pharmacokinetic, and target engagement findings from the study.<\/p>\n<p>\n        <b>Poster presentation<\/b><br \/>\n        <br \/>\n        <b>Title:<\/b> Safety, pharmacokinetics and target engagement of AX-0810 a first-in-class RNA editing therapy designed to modulate bile acid transport for cholestatic disease<br \/><b>Abstract number:<\/b> 1156<br \/><b>Presenter:<\/b> R. Bart Takkenberg, MD, PhD, Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam<br \/><b>Date and time:<\/b> November 5, 2026, 12:00pm-1:00pm MT<br \/><b>Location: <\/b>Denver, CO<\/p>\n<p>\n        <b>Late-breaking poster presentation<\/b><br \/>\n        <br \/>\n        <b>Title:<\/b> First-in-person evidence of in vivo Axiomer RNA Editing of NTCP for the treatment of cholestasis: Proof of concept data from the AX-0810 Phase 1 Trial<br \/><b>Late-breaking abstract number:<\/b> 5032<br \/><b>Presenter:<\/b> R. Bart Takkenberg, MD, PhD, Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam<br \/><b>Date and time:<\/b> November 8, 2026, 1:00pm-2:00pm MT<br \/><b>Location:<\/b> Denver, CO<\/p>\n<p>\n        <b>Nature Conferences RNA at the Bench and Bedside V<\/b>\n      <\/p>\n<p>Cohort 3 data and the 12 week follow up from the AX-0810 Phase 1 study and new preclinical proof-of-concept data for AX-0811 will be presented at Nature\u2019s RNA at the Bench and Bedside V in December 2026.<\/p>\n<p>\n        <b>Presentation title:<\/b> From clinical validation to next-generation ADAR RNA editing: Advancing NTCP modulation with AX-0810 and AX-0811 for cholestatic disease<br \/><b>Presenter:<\/b> Gerard Platenburg, Chief Scientific Officer<br \/><b>Date and time:<\/b> December 9, 2026, 2:30-3:00pm PT<br \/><b>Location:<\/b> La Jolla, California<\/p>\n<p>Building on the clinical experience with AX-0810 and encouraging preclinical proof-of-concept findings, AX-0811, a next-generation NTCP-targeting RNA editing oligonucleotide designed with improved potency and durability is being evaluated in a Phase 1 study in healthy volunteers with initial data expected in early January 2027.<\/p>\n<p>The presentations and posters will be made available on the Publications and Presentations section of ProQR\u2019s website following their presentation, subject to applicable conference policies.<\/p>\n<p>\n        <b>About Axiomer<\/b><br \/>\n        <sup><br \/>\n          <b>\u2122<\/b><br \/>\n        <\/sup>\n      <\/p>\n<p>ProQR is pioneering a next-generation RNA base editing technology called Axiomer<sup>\u2122<\/sup>, which could potentially yield a new class of medicines for diverse types of diseases. Axiomer<sup>\u2122<\/sup> \u201cEditing Oligonucleotides\u201d, or EONs, mediate single nucleotide changes to RNA in a highly specific and targeted way using molecular machinery that is present in human cells called ADAR (Adenosine Deaminase Acting on RNA). Axiomer<sup>\u2122<\/sup> EONs are designed to recruit and direct endogenously expressed ADARs to change an Adenosine (A) to an Inosine (I) in the RNA \u2013 an Inosine is translated as a Guanosine (G) \u2013 correcting an RNA with a disease-causing mutation back to a normal (wild type) RNA, modulating protein expression, or altering a protein so that it will have a new function that helps prevent or treat disease. <\/p>\n<p>\n        <b>About ProQR<\/b>\n      <\/p>\n<p>ProQR Therapeutics is a clinical-stage company dedicated to changing lives through the creation of transformative RNA therapies. ProQR is pioneering a next-generation RNA technology called Axiomer<sup>\u2122<\/sup>, which uses a cell\u2019s own editing machinery called ADAR to make specific single nucleotide edits in RNA to reverse a mutation or modulate protein expression and could potentially yield a new class of medicines for both rare and prevalent diseases with unmet need. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.<\/p>\n<p>Learn more about ProQR at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pv9MQ6Lq1XLBK3BxuEPFX3naAES87lHQZNdv5A9o6FK5JmEv1nw2E6feYQRaBgTSZM1SuRmZNelsZDFnd6IjsQ==\" rel=\"nofollow\" target=\"_blank\"><b>www.proqr.com<\/b><\/a>.<\/p>\n<p>\n        <b>Forward Looking Statements <\/b>\n      <\/p>\n<p>This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccould,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cshould,\u201d \u201cwill,\u201d \u201cwould\u201d and similar expressions. Such forward-looking statements include, but are not limited to, statements regarding the timing and content of ProQR\u2019s upcoming presentations at TIDES Europe, The Liver Meeting 2026, and Nature Conferences RNA at the Bench and Bedside V; as well as ProQR\u2019s participation in these conferences; the availability of ProQR\u2019s presentations and posters on its website; the planned presentation of Cohort 3 data and 12 week follow up from the AX-0810 Phase 1 study and new preclinical proof-of-concept data for AX-0811; the continued development and advancement of the Axiomer platform and ProQR\u2019s NTCP-targeting programs; the potential for greater potency and durability of AX-0811 observed preclinically to translate into humans; the Phase 1 clinical development of AX-0811 in healthy volunteers, including enrollment of the trial and the anticipated timing of initial clinical data in early January 2027; the therapeutic potential of Axiomer EONs and ProQR\u2019s product candidates; and the anticipated benefits of ProQR\u2019s AI-enabled discovery engine.<\/p>\n<p>Forward-looking statements are based on management\u2019s beliefs and assumptions and on information available to management only as of the date of this press release. Actual results could differ materially from those expressed or implied by these forward-looking statements for many reasons, including, without limitation, the risks, uncertainties and other factors described in ProQR\u2019s filings with the Securities and Exchange Commission, including certain sections of its most recent annual report on Form 20-F. These risks and uncertainties include, among others, the cost, timing and results of preclinical studies and clinical trials and other development activities; the risk that preclinical or early clinical data may not be predictive of future results or clinical benefit; the likelihood that ProQR\u2019s programs may not advance on the timelines currently anticipated; reliance on contract research organizations, contract manufacturers and other third parties; the ability to recruit and retain employees and consultants, including members of management and scientific advisors; the ability to integrate and realize the anticipated benefits of AI, machine learning and proprietary data in discovery and development; the unpredictability of regulatory requirements and the duration and results of regulatory review; possible safety or efficacy concerns that may emerge as additional data are generated; the possible impairment of, inability to obtain or costs to obtain intellectual property rights; the ability to secure, maintain and realize the intended benefits of collaborations and partnerships; risks related to cybersecurity and data privacy; general business, operational, financial and accounting risks; and risks related to macroeconomic conditions, market volatility, geopolitical events, international trade restrictions and other developments affecting ProQR\u2019s business. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements. ProQR assumes no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.<\/p>\n<p>\n        <b>ProQR Therapeutics N.V.<\/b>\n      <\/p>\n<p>\n        <b>Investor and media contact:<\/b><br \/>\n        <br \/>Sarah Kiely<br \/>ProQR Therapeutics N.V.<br \/>T: +1 617 599 6228<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=nIwQXUdks62W5A1eh2Hdo_IusNyKa7qAqTNp2v54g6hMboaY0SfsysPIXVNrCQXpgKVLNSlPzz-5aboC6N6xtv9Mj-jBZNzXd6iYBjmGesc=\" rel=\"nofollow\" target=\"_blank\"><b>skiely@proqr.com<\/b><\/a><br \/>or<br \/><b>Investor contact:<\/b><br \/>Peter Kelleher<br \/>LifeSci Advisors<br \/>T: +1 617 430 7579 <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Qc7Y0Ts6vhLFZxtSgtt1OQKLE6lu5I49QJzJgGW07DgURTSczyI-VT1Ju6c3H2DQdFskYVVBA10BDCX8q6hCtXvLdvjCWSyxuQI3UsSwod3oiib2QgBTydrlrCqIHO8g\" rel=\"nofollow\" target=\"_blank\"><b>pkelleher@lifesciadvisors.com<\/b><\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMTI4MDM1OCM0MDI1MzQ1MzQjMjAxMTE2Nw==\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml-eu.globenewswire.com\/media\/YjAwOGYyZjMtNjc4NC00YmI2LWFhMWQtNmMwNjE1NmU1ZGViLTEwMjI3NDAtMjAyNi0xMC0yOC1lbg==\/tiny\/ProQR-Therapeutics-N-V-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>ProQR to present its ADAR-mediated RNA editing approach and progress toward next-generation editing oligonucleotides at TIDES Europe plenary session AX-0810 Phase 1 data to be featured in two poster presentations at AASLD, The Liver Meeting\u00ae 2026, including one late-breaking poster Cohort 3 data and the 12 week follow up from the AX-0810 Phase 1 study along with new preclinical proof-of-concept data for AX-0811 to be presented at Nature Conferences RNA at the Bench and Bedside V in December 2026 Next-generation AX-0811, an NTCP-targeting RNA editing oligonucleotide generated using ProQR\u2019s AI-enabled discovery engine is being evaluated in a Phase 1 study in healthy volunteers, with initial data expected in early January 2027 LEIDEN, Netherlands &amp; CAMBRIDGE, Mass., Oct. 28, 2026 (GLOBE &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/proqr-to-present-clinical-and-preclinical-progress-from-ax-0810-and-ax-0811-at-upcoming-conferences\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;ProQR to Present Clinical and Preclinical Progress from AX-0810 and AX-0811 at Upcoming Conferences&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1014614","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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