{"id":1013076,"date":"2026-10-23T07:36:33","date_gmt":"2026-10-23T11:36:33","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\/"},"modified":"2026-10-23T07:36:33","modified_gmt":"2026-10-23T11:36:33","slug":"briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\/","title":{"rendered":"BriaCell Announces ESMO 2026 Poster Highlighting Circulating Immune Biomarker Associated with Clinical Outcomes in Metastatic Breast Cancer"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Dynamic changes in PD-L1 expression on circulating cancer-associated macrophage-like cells (CAML) were significantly associated with progression-free survival and overall survival following immunotherapies including the BriaCell regimen<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Findings from a prospective pooled analysis of 111 heavily pretreated metastatic breast cancer patients support further evaluation of circulating CAML PD-L1 as a potential biomarker of clinical benefit from immunotherapies<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Pooled analysis includes patients from multiple studies, including BriaCell\u2019s earlier Phase 1\/2 Bria-IMT\u2122 study<\/em><br \/>\n          <\/strong><br \/>\n          \n        <\/li>\n<\/ul>\n<p align=\"justify\">PHILADELPHIA and VANCOUVER, British Columbia, Oct.  23, 2026  (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, today announced the presentation of clinical biomarker findings from a prospective pooled analysis of patients with metastatic breast cancer (\u201cMBC\u201d) treated with immune based therapies including the BriaCell regimen at the European Society for Medical Oncology (\u201cESMO\u201d) Congress 2026, taking place October 23-27, 2026 in Madrid, Spain. The data shown is pooled from several studies including BriaCell\u2019s Phase 1\/2 Bria-IMT study.<\/p>\n<p align=\"justify\">The analysis evaluated changes in programmed death-ligand 1 (\u201cPD-L1\u201d) expression on circulating cancer-associated macrophage-like cells (\u201cCAMLs\u201d) before and after initiation of immunotherapy and their association with progression-free survival (\u201cPFS\u201d) and overall survival (\u201cOS\u201d). The findings suggest that changes in CAML PD-L1 following treatment may provide information regarding clinical outcomes that are not captured by a single pretreatment measurement.<\/p>\n<p align=\"justify\">\u201cWe are encouraged by these findings showing that dynamic changes in a circulating immune biomarker were associated with progression-free and overall survival in patients with metastatic breast cancer treated with immunotherapies,\u201d stated Dr. William V. Williams, BriaCell\u2019s President and CEO. \u201cThese results support further study of CAML PD-L1 as a potential tool for understanding treatment response and identifying patients most likely to benefit from immunotherapy, including the Bria-IMT regimen.\u201d<\/p>\n<p align=\"justify\">\n        <strong>Poster #4506 &#8211;<\/strong><br \/>\n        <strong>Monitoring Circulating Cancer Associated Macrophage-like Cell PD-L1 Predicts Clinical Outcomes in Metastatic Breast Cancer Treated with Immune Checkpoint Inhibitors<\/strong>\n      <\/p>\n<p align=\"justify\">The prospective, multi-institutional pooled analysis included 111 patients with MBC who had received at least one prior line of therapy and were treated with pembrolizumab, retifanlimab, atezolizumab, or nivolumab. Some also received combination therapy with the Bria-IMT regimen. Patients had a median age of 59 years, with a range of 32 to 77 years, and had received a median of two prior metastatic lines of therapy, with a range of one to 13.<\/p>\n<p align=\"justify\">Among the 111 patients, 39% were estrogen receptor-positive, 31% were progesterone receptor-positive, 5% were HER2-positive, and 60% had triple-negative breast cancer.<\/p>\n<p align=\"justify\">Peripheral blood samples were collected prior to initiation of immunotherapy, approximately 37 days after initiation of immunotherapy (\u201cT1\u201d), and approximately three months after initiation of immunotherapy (\u201cT2\u201d). CAMLs were isolated from blood samples, and PD-L1 expression was categorized as low or high.<\/p>\n<p align=\"justify\">\n        <u>Key findings included:<\/u>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">At baseline, CAML PD-L1 was not significantly associated with either PFS or OS.<\/li>\n<li style=\"text-align:justify\">At T1, approximately 37 days following initiation of immunotherapy, CAML PD-L1 was significantly associated with PFS (HR=1.86; p=0.0276), but not OS (HR=1.28; p=0.5663).<\/li>\n<li style=\"text-align:justify\">At T2, approximately three months following initiation of immunotherapy, CAML PD-L1 was significantly associated with both PFS (HR=2.73; p=0.0028) and OS (HR=2.27; p=0.0420).<\/li>\n<li style=\"text-align:justify\">Pretreatment tumor PD-L1 combined positive score (\u201cCPS\u201d) of 10 or greater was not significantly associated with improved PFS or OS in the pooled population.<\/li>\n<\/ul>\n<p align=\"justify\">\u201cThese findings suggest that monitoring dynamic PD-L1 changes in circulating tumor-associated immune cells following initiation of immunotherapy may provide information regarding clinical benefit in patients with MBC and are consistent with findings reported in the Bria-IMT Phase 2 study,\u201d stated Giuseppe Del Priore, MD, MPH, BriaCell\u2019s Chief Medical Officer. \u201cFurther studies are needed to validate CAML PD-L1 as a predictive biomarker.\u201d<\/p>\n<p align=\"justify\">\n        <strong><br \/>\n          <u>About BriaCell\u2019s Pivotal Phase 3 Clinical Study of Bria-IMT Combination Regimen in MBC patients<\/u><br \/>\n        <\/strong>\n      <\/p>\n<p align=\"justify\">BriaCell\u2019s pivotal Phase 3 study of Bria-IMT plus an immune check point inhibitor (CPI) in metastatic breast cancer is ongoing.<\/p>\n<p align=\"justify\">The study\u2019s primary endpoint is overall survival, comparing patients treated with the Bria-IMT combination regimen with patients receiving physician\u2019s choice treatment. The planned interim analysis will be conducted following 144 patient deaths. Positive results from the pivotal Phase 3 study could support a potential application for marketing approval of Bria-IMT in metastatic breast cancer. <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=DlslPgeXkHWqjR6FxrCRuVREIvSx5xIrsDKfT9M6VGTnDbL5bIGcOKwVaPNqFgNGsDrbf8h_PMSPrv0pN5n_sPx1_2EnyfeeNEUZATC2Sg4prD-4d9Nh9qbBORHjmOESUxZwDpyH4yilm8BxkIC4lfiyYfcKdWcWaYmjF48_Yo0PYuHQNJye__po3JPFnsuoDddCxT_LJNhq4MBw7Ipt_KqsnH8NV9BK909Sb6Xu8z4_BhYxp_cEmUMt085vOClTYKsm_58VXgRsCG2EifIhHoE4GiczTTn5sKuKf6e2xwSwPkQwWzm3dj5mp1dIlHerB_H5etfjrokb-VBw6Q9WMQ==\" rel=\"nofollow\" target=\"_blank\">BriaCell reported positive Phase 2 survival data in a similar MBC patient population treated with the same Bria-IMT combination regimen<\/a>. The Bria-IMT combination regimen has received FDA Fast Track designation.<\/p>\n<p align=\"justify\">For additional information on BriaCell\u2019s pivotal Phase 3 study of Bria-IMT and an immune check point inhibitor in metastatic breast cancer, please visit ClinicalTrials.gov <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=QtlgakCI31K1F0efl-AnIE7UgqPN7rNIvoY_yILyYQfKOgoYY7qUsj_j32LZ67CGi8ARW37OSxJ56we4k5GkdOycmGSJuTGevVbvxTRtOK_1A7cIDxO7vRbPRe2EAAkJ\" rel=\"nofollow\" target=\"_blank\">NCT06072612<\/a>.<\/p>\n<p align=\"justify\">A copy of the poster presentation is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=8oroSzrAuoDSlY9nqXDfucr8yGs8shvg25YPNcNfop4u4_gGWLNe1rnl3P3cryu0WCRzoblWP3Gy5HBhFVViCQQM2DlZWFQSynX_iJKH5LPipq-XgLeWHniJ1y9sxxcnrX5BUdK_5DRzO2gp2lbg559N1NxVHrlNlI7vJqndvfs=\" rel=\"nofollow\" target=\"_blank\">https:\/\/briacell.com\/scientific-publications\/<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>About BriaCell Therapeutics Corp.<\/strong>\n      <\/p>\n<p align=\"justify\">BriaCell is an immuno-oncology-focused biotechnology company developing targeted and effective approaches for the management of cancer. More information is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=8oroSzrAuoDSlY9nqXDfucr8yGs8shvg25YPNcNfop4RdS_kPwhNLwnT6R1fH_yXop7ZvFWZNrtqsEWS9JJxHL_k472u3kFg1m3AI_BiNIg=\" rel=\"nofollow\" target=\"_blank\">https:\/\/briacell.com\/<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>Safe Harbor<\/strong>\n      <\/p>\n<p align=\"justify\">This press release contains \u201cforward-looking statements\u201d that are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release may be identified by the use of words such as \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccontemplate,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cseek,\u201d \u201cmay,\u201d \u201cmight,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201ctarget,\u201d \u201caim,\u201d \u201cshould,\u201d \u201cwill,\u201d \u201cwould,\u201d or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements, including those about the presentation of clinical data at the ESMO Congress 2026, and the contents of all such presentations, the early constructive clinical biomarker data allowing the Company to predict clinical and survival outcomes and guide treatment decisions for metastatic breast cancer patients, and the Company\u2019s anticipated timing of analysis of interim data, are based on BriaCell\u2019s current expectations and are subject to inherent uncertainties, risks, and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading \u201cRisks and Uncertainties\u201d in the Company\u2019s most recent Management\u2019s Discussion and Analysis, under the heading \u201cRisk Factors\u201d in the Company\u2019s most recent Annual Information Form, and under \u201cRisks and Uncertainties\u201d in the Company\u2019s other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission, all of which are available under the Company\u2019s profiles on SEDAR+ at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=IwiAlChqwPGVLU7nKAYGWFuqHm2bVyJ2oV8VWZgARm2iWbEJH4zFZ4aWrM-AsctDH1Cd9e21MZCtD3AxstOHJ-5srd8qEtCeLDA9nzGB3RE=\" rel=\"nofollow\" target=\"_blank\"><strong>www.sedarplus.ca<\/strong><\/a> and on EDGAR at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=IwiAlChqwPGVLU7nKAYGWFk8tcHwmM1qK8LFRbi3rylVg9mNir1oGIQtxZoDFPbIykUAjP-P0OLTWceCocFSKg==\" rel=\"nofollow\" target=\"_blank\"><strong>www.sec.gov<\/strong><\/a>. Forward-looking statements contained in this announcement are made as of this date, and BriaCell Therapeutics Corp. undertakes no duty to update such information except as required under applicable law.<\/p>\n<p align=\"justify\">Neither the Toronto Stock Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange) accepts responsibility for the adequacy or accuracy of this release.<\/p>\n<p align=\"left\">\n        <strong>Contact Information<\/strong>\n      <\/p>\n<p align=\"left\">\n        <strong>Company Contact:<\/strong><br \/>\n        <br \/>William V. Williams, MD<br \/>President &amp; CEO<br \/>1-888-485-6340<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=kCjQE7U0QM6qZsl6mZMGT-e_z9ikmsfeQLEDV9C95AK8Mss9ejbeJEKQwLtziI__Kon2XVCDKK_UKtuCFGv5-wdWYu9qdTx-bAmlgtG69Po=\" rel=\"nofollow\" target=\"_blank\">info@briacell.com<\/a>\u00a0<\/p>\n<p align=\"left\">\n        <strong>Investor Relations Contact:<\/strong><br \/>\n        <br \/>\n        <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=6Vrr4W4JKALJg1Cz1OwMsRuXzTLF_Fz8ny29PrwyYr6ner9fHmytoIkRmN9OwgEBrSGZsnUj3XDEN3ld6Qu5zvDZ6Rh8GzbOC_PsC79iEQA=\" rel=\"nofollow\" target=\"_blank\">investors@briacell.com<\/a>\n      <\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTg1MTg1NCM3OTEyNTI0IzIwOTA2NTg=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/Y2NjODRiZTAtNDRkOC00NzkxLWE2ZjYtMmE0YzlmN2VhNGI5LTExMDIyMjktMjAyNi0xMC0yMy1lbg==\/tiny\/BriaCell-Therapeutics-Corp-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dynamic changes in PD-L1 expression on circulating cancer-associated macrophage-like cells (CAML) were significantly associated with progression-free survival and overall survival following immunotherapies including the BriaCell regimen Findings from a prospective pooled analysis of 111 heavily pretreated metastatic breast cancer patients support further evaluation of circulating CAML PD-L1 as a potential biomarker of clinical benefit from immunotherapies Pooled analysis includes patients from multiple studies, including BriaCell\u2019s earlier Phase 1\/2 Bria-IMT\u2122 study PHILADELPHIA and VANCOUVER, British Columbia, Oct. 23, 2026 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, today announced the presentation of clinical biomarker findings from a prospective pooled analysis of patients with &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;BriaCell Announces ESMO 2026 Poster Highlighting Circulating Immune Biomarker Associated with Clinical Outcomes in Metastatic Breast Cancer&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1013076","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BriaCell Announces ESMO 2026 Poster Highlighting Circulating Immune Biomarker Associated with Clinical Outcomes in Metastatic Breast Cancer - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BriaCell Announces ESMO 2026 Poster Highlighting Circulating Immune Biomarker Associated with Clinical Outcomes in Metastatic Breast Cancer - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Dynamic changes in PD-L1 expression on circulating cancer-associated macrophage-like cells (CAML) were significantly associated with progression-free survival and overall survival following immunotherapies including the BriaCell regimen Findings from a prospective pooled analysis of 111 heavily pretreated metastatic breast cancer patients support further evaluation of circulating CAML PD-L1 as a potential biomarker of clinical benefit from immunotherapies Pooled analysis includes patients from multiple studies, including BriaCell\u2019s earlier Phase 1\/2 Bria-IMT\u2122 study PHILADELPHIA and VANCOUVER, British Columbia, Oct. 23, 2026 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, today announced the presentation of clinical biomarker findings from a prospective pooled analysis of patients with &hellip; Continue reading &quot;BriaCell Announces ESMO 2026 Poster Highlighting Circulating Immune Biomarker Associated with Clinical Outcomes in Metastatic Breast Cancer&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-23T11:36:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTg1MTg1NCM3OTEyNTI0IzIwOTA2NTg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"BriaCell Announces ESMO 2026 Poster Highlighting Circulating Immune Biomarker Associated with Clinical Outcomes in Metastatic Breast Cancer\",\"datePublished\":\"2026-10-23T11:36:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\\\/\"},\"wordCount\":1134,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTg1MTg1NCM3OTEyNTI0IzIwOTA2NTg=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-announces-esmo-2026-poster-highlighting-circulating-immune-biomarker-associated-with-clinical-outcomes-in-metastatic-breast-cancer\\\/\",\"name\":\"BriaCell Announces ESMO 2026 Poster Highlighting Circulating Immune Biomarker Associated with Clinical Outcomes in Metastatic Breast Cancer - 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