{"id":1006128,"date":"2026-09-28T07:37:11","date_gmt":"2026-09-28T11:37:11","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/"},"modified":"2026-09-28T07:37:11","modified_gmt":"2026-09-28T11:37:11","slug":"sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/","title":{"rendered":"Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026"},"content":{"rendered":"
\n

FOSTER CITY, Calif., Sept. 28, 2026 (GLOBE NEWSWIRE) — Sagimet Biosciences Inc. (Nasdaq: SGMT), a clinical-stage biopharmaceutical company developing novel therapeutics targeting dysfunctional metabolic and fibrotic pathways, today announced that it will host a virtual key opinion leader (KOL) event on Wednesday, September 30, 2026, at 1:00 PM ET featuring Julie Harper, MD, Founding Director and past President of the American Acne and Rosacea Society. To register, click here<\/a>.<\/p>\n

Dr. Harper will join company management for a review of the 52-week data from license partner Ascletis\u2019 Phase 3 open-label extension clinical trial of denifanstat in moderate to severe acne vulgaris in China and an update on Sagimet\u2019s planned U.S. Phase 3 AURORA clinical trial of denifanstat for the treatment of moderate to severe acne.<\/p>\n

In the Phase 3 open-label extension clinical trial, subjects treated with denifanstat showed improvements in all efficacy endpoints (secondary endpoints of the trial) beyond those observed at 12 weeks in the original clinical trial. Denifanstat was generally well-tolerated in both the original clinical trial and the open-label extension clinical trial. These efficacy results will be presented at the European Academy of Dermatology and Venereology Congress (EADV 2026), building on the topline results announced in February 2026.<\/p>\n

Sagimet\u2019s AURORA Phase 3 clinical trial of denifanstat in moderate to severe acne in the U.S. is expected to initiate in the fourth quarter of 2026.<\/p>\n

Denifanstat is a once-daily oral small molecule fatty acid synthase (FASN) inhibitor with a novel mechanism of action in development to address moderate to severe acne, a condition that impacts approximately 10 million people annually in the U.S.<\/p>\n

A live question and answer session will follow the formal presentations. A replay of this event will be available in the Investors & Media section of Sagimet\u2019s website at\u00a0www.sagimet.com<\/a>\u00a0for 90 days following the live event.<\/p>\n

\n About Julie Harper, MD<\/strong>\n <\/p>\n

Julie Harper, MD is a board-certified dermatologist in private practice at the Dermatology and Skin Care Center of Birmingham in Birmingham, Alabama. She received her medical training at the University of Missouri-Columbia, where she also completed her internship and dermatology residency. Dr. Harper transitioned from residency training into an academic dermatology career at the University of Alabama-Birmingham (UAB). While at UAB, she was promoted to Associate Professor. During that time, she developed a special interest in acne and rosacea, participating in acne clinical trials and writing and speaking on the subject locally and nationally.<\/p>\n

Dr. Harper is a Founding Director of the American Acne and Rosacea Society and is the organization\u2019s past-President. In 2007, Dr. Harper founded a private practice in dermatology where she practices general medical, surgical and cosmetic dermatology. She is a Fellow of the American Academy of Dermatology (AAD) and recently served on the AAD\u2019s Acne Work Group, tasked with writing acne treatment guidelines. Dr. Harper is also a member of the Women\u2019s Dermatologic Society and a former President of the Alabama Dermatological Society.<\/p>\n

\n About the AURORA Phase 3 Clinical Trial<\/strong>\n <\/p>\n

The AURORA multi-center, randomized, double-blind, placebo-controlled Phase 3 clinical trial of denifanstat in moderate to severe acne is intended to enroll approximately 800 U.S. patients aged 12 years and older, of which 450 are expected to be adolescents aged 12 to 17 years. Patients will be randomized 2:1 to receive denifanstat 50 mg or placebo once daily for 12 weeks. The trial will have three co-primary endpoints that will be assessed at week 12: the proportion of patients achieving treatment success in a global assessment score, defined as at least a 2-point reduction from baseline with a score of 0 (clear) or 1 (almost clear); absolute change in inflammatory skin lesion counts from baseline; and absolute change in non-inflammatory skin lesion counts from baseline. A subset of approximately 530 patients completing the double-blind period will be eligible to enter a 40-week open-label extension evaluating the long-term safety of denifanstat.<\/p>\n

\n About Denifanstat<\/strong>\n <\/p>\n

Denifanstat is an oral, once-daily FASN inhibitor in development for the treatment of moderate to severe acne. In trials conducted by Sagimet\u2019s license partner,\u00a0Ascletis BioScience Co. Ltd.\u00a0(Ascletis) in\u00a0China, denifanstat met all primary and secondary endpoints in a 12 week randomized, double-blind Phase 3 clinical trial in moderate to severe acne vulgaris and was generally well-tolerated and showed improvements in all efficacy endpoints measured at 52 weeks (secondary endpoints of the trial) in an open-label extension clinical trial evaluating denifanstat\u2019s long-term safety in patients with moderate to severe acne. Denifanstat is being developed by\u00a0Ascletis\u00a0as ASC40 for acne in\u00a0China\u00a0and by Sagimet in the rest of world.<\/p>\n

\n About Acne<\/strong>\n <\/p>\n

Acne is one of the most common skin conditions in the\u00a0U.S., with approximately 50 million Americans affected annually and more than 5 million seeking medical treatment for acne each year. Acne affects around 85% of persons between the ages of 12 and 24. Moderate to severe acne accounts for 20% of acne sufferers, or approximately 10 million people in the\u00a0U.S.\u00a0annually. There is no cure for acne, and due to its pathology, most patients require chronic management and multiple annual courses of treatment for flare control.<\/p>\n

\n About\u00a0Sagimet Biosciences<\/strong>\n <\/p>\n

Sagimet is a clinical-stage biopharmaceutical company developing novel FASN inhibitors designed to target dysfunctional metabolic and fibrotic pathways in conditions resulting from the overproduction of the fatty acid, palmitate. FASN is a regulator of lipid synthesis, a key pathway implicated in multiple diseases, such as acne, MASH\u202fand certain FASN-dependent tumor types. For additional information about Sagimet, please visit\u00a0www.sagimet.com<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>\n <\/p>\n

This press release contains forward-looking statements within the meaning of, and made pursuant to the safe harbor provisions of, The Private Securities Litigation Reform Act of 1995. All statements contained in this press release, other than statements of historical facts or statements that relate to present facts or current conditions, including but not limited to, statements regarding the expected timing of the presentation of data from ongoing clinical trials, Sagimet\u2019s clinical development plans and related timelines and anticipated development milestones, are forward-looking statements. These statements involve known and unknown risks, uncertainties and other important factors that may cause Sagimet\u2019s actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. In some cases, these statements can be identified by terms such as \u201cmay,\u201d \u201cmight,\u201d \u201cwill,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201caim,\u201d \u201cseek,\u201d \u201canticipate,\u201d \u201ccould,\u201d \u201cintend,\u201d \u201ctarget,\u201d \u201cproject,\u201d \u201ccontemplate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cpredict,\u201d \u201cforecast,\u201d \u201cpotential\u201d or \u201ccontinue\u201d or the negative of these terms or other similar expressions. The forward-looking statements in this press release are only predictions. Sagimet has based these forward-looking statements largely on its current expectations and projections about future events and financial trends that Sagimet believes may affect its business, financial condition and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond Sagimet\u2019s control, including, among others: the clinical development and therapeutic potential of denifanstat, TVB-3567 or any other drug candidates or combination therapies developed by Sagimet; Sagimet\u2019s ability to advance drug candidates into and successfully complete clinical trials within anticipated timelines; Sagimet\u2019s relationship with Ascletis, and the success of its development and registration efforts for denifanstat; the accuracy of Sagimet\u2019s estimates regarding its capital requirements and Sagimet\u2019s ability to maintain and successfully enforce adequate intellectual property protection. These and other risks and uncertainties are described more fully in the \u201cRisk Factors\u201d section of Sagimet\u2019s most recent filings with the Securities and Exchange Commission and available at www.sec.gov. You should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in these forward-looking statements may not be achieved or occur, and actual results could differ materially from those projected in the forward-looking statements. Moreover, Sagimet operates in a dynamic industry and economy. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties that Sagimet may face. Except as required by applicable law, Sagimet does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.<\/p>\n

\n Investor Contact:<\/strong>
\n
Joyce Allaire\u00a0
LifeSci Advisors\u00a0
JAllaire@LifeSciAdvisors.com<\/a><\/p>\n

\n Media Contact:<\/strong>
\n
Maggie Whitney
LifeSci Communications
mwhitney@lifescicomms.com<\/a><\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

FOSTER CITY, Calif., Sept. 28, 2026 (GLOBE NEWSWIRE) — Sagimet Biosciences Inc. (Nasdaq: SGMT), a clinical-stage biopharmaceutical company developing novel therapeutics targeting dysfunctional metabolic and fibrotic pathways, today announced that it will host a virtual key opinion leader (KOL) event on Wednesday, September 30, 2026, at 1:00 PM ET featuring Julie Harper, MD, Founding Director and past President of the American Acne and Rosacea Society. To register, click here. Dr. Harper will join company management for a review of the 52-week data from license partner Ascletis\u2019 Phase 3 open-label extension clinical trial of denifanstat in moderate to severe acne vulgaris in China and an update on Sagimet\u2019s planned U.S. Phase 3 AURORA clinical trial of denifanstat for the treatment of … <\/p>\n

Continue reading “Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1006128","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nSagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"FOSTER CITY, Calif., Sept. 28, 2026 (GLOBE NEWSWIRE) — Sagimet Biosciences Inc. 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Dr. Harper will join company management for a review of the 52-week data from license partner Ascletis\u2019 Phase 3 open-label extension clinical trial of denifanstat in moderate to severe acne vulgaris in China and an update on Sagimet\u2019s planned U.S. Phase 3 AURORA clinical trial of denifanstat for the treatment of … Continue reading "Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-28T11:37:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgzNDczNSM3ODY1OTMyIzIyMDg2NDg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026\",\"datePublished\":\"2026-09-28T11:37:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\\\/\"},\"wordCount\":1401,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTgzNDczNSM3ODY1OTMyIzIyMDg2NDg=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\\\/\",\"name\":\"Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026 - 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(Nasdaq: SGMT), a clinical-stage biopharmaceutical company developing novel therapeutics targeting dysfunctional metabolic and fibrotic pathways, today announced that it will host a virtual key opinion leader (KOL) event on Wednesday, September 30, 2026, at 1:00 PM ET featuring Julie Harper, MD, Founding Director and past President of the American Acne and Rosacea Society. To register, click here. Dr. Harper will join company management for a review of the 52-week data from license partner Ascletis\u2019 Phase 3 open-label extension clinical trial of denifanstat in moderate to severe acne vulgaris in China and an update on Sagimet\u2019s planned U.S. Phase 3 AURORA clinical trial of denifanstat for the treatment of … Continue reading \"Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/","og_site_name":"Market Newsdesk","article_published_time":"2026-09-28T11:37:11+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgzNDczNSM3ODY1OTMyIzIyMDg2NDg=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026","datePublished":"2026-09-28T11:37:11+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/"},"wordCount":1401,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgzNDczNSM3ODY1OTMyIzIyMDg2NDg=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/sagimet-biosciences-to-host-virtual-kol-event-denifanstat-update-52-week-data-from-phase-3-open-label-extension-in-china-and-planned-aurora-phase-3-clinical-trial-in-us-on-septembe\/","name":"Sagimet Biosciences to Host Virtual KOL Event, \u201cDenifanstat Update: 52-Week Data from Phase 3 Open-Label Extension in China and Planned AURORA Phase 3 Clinical Trial in US\u201d on September 30, 2026 - 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