{"id":1001114,"date":"2026-09-08T08:03:53","date_gmt":"2026-09-08T12:03:53","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/coya-therapeutics-announces-publication-of-preclinical-study-demonstrating-combination-immunomodulatory-effects-of-coya-303-in-a-well-established-model-of-peripheral-and-cns-inflammation\/"},"modified":"2026-09-08T08:03:53","modified_gmt":"2026-09-08T12:03:53","slug":"coya-therapeutics-announces-publication-of-preclinical-study-demonstrating-combination-immunomodulatory-effects-of-coya-303-in-a-well-established-model-of-peripheral-and-cns-inflammation","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/coya-therapeutics-announces-publication-of-preclinical-study-demonstrating-combination-immunomodulatory-effects-of-coya-303-in-a-well-established-model-of-peripheral-and-cns-inflammation\/","title":{"rendered":"Coya Therapeutics Announces Publication of Preclinical Study Demonstrating Combination Immunomodulatory Effects of COYA 303 in a Well-Established Model of Peripheral and CNS Inflammation"},"content":{"rendered":"

<\/p>\n

Coya Therapeutics Announces Publication of Preclinical Study Demonstrating Combination Immunomodulatory Effects of COYA 303 in a Well-Established Model of Peripheral and CNS Inflammation<\/b><\/p>\n

Study results showed complementary immunomodulatory effects of COYA 303, a combination of proprietary low-dose IL-2 (LD-IL2) and a GLP-1 Receptor Agonist (GLP-1RA), compared to either LD-IL2 or GLP-1RA as monotherapy<\/i><\/p>\n

GLP-1RA attenuated myeloid expansion and inflammatory transcriptional responses, whereas LD-IL2 increased Treg numbers and transcripts associated with Treg stability and suppressive function<\/i><\/p>\n

Coya believes findings support further evaluation of COYA 303 and combination approaches in addressing Alzheimer\u2019s disease and other complex neurodegenerative indications<\/i><\/p>\n

Coya will continue to pursue non-dilutive avenues and potential partnerships to advance the COYA 303 program<\/i><\/p>\n

HOUSTON–(BUSINESS WIRE<\/a>)–Coya Therapeutics, Inc.<\/a> (NASDAQ: COYA) (\u201cCoya\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing biologics intended to enhance Treg function, today announced the publication of preclinical results for COYA 303 in the International Journal of Molecular Sciences<\/i>. The article was published as part of the Special Issue, \u201cThe Roles of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Health and Disease,\u201d which highlights the expanding therapeutic applications of GLP-1 receptor agonists across diverse disease settings, including their emerging immunomodulatory effects.<\/p>\n

COYA 303 is a combination of proprietary low-dose IL-2 (LD-IL2) and a GLP-1 receptor agonist (GLP-1RA), and was evaluated in a subacute low-dose lipopolysaccharide (LPS) mouse model. The LPS mouse model recapitulates key features relevant to neurodegenerative diseases, including increased pro-inflammatory signaling and myeloid activation, leading to immune dysregulation, providing a validated setting for testing potential therapeutic interventions. The study evaluated whether simultaneously attenuating inflammatory myeloid activity and reinforcing Treg-mediated immune regulation could produce broader immunomodulatory effects than either approach alone.<\/p>\n

\u201c<\/strong>We are encouraged by these preclinical findings, which we believe demonstrate the therapeutic potential of immunomodulatory combinations for the treatment of serious neurodegenerative diseases characterized by sustained inflammation,\u201d said Fred Grossman, DO, FAPA, President and Chief Medical Officer of Coya. \u201cThese results continue to reinforce our belief that complex neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer\u2019s disease (AD) are best addressed through a combination approach and suggest that further evaluation of this approach in chronic, disease-relevant models are needed to better understand its potential.\u201d<\/p>\n

Summary of Study Results<\/span><\/b><\/i><\/p>\n

Study animals treated with the GLP-1RA and LD-IL2 combination showed statistically significant and clear directional effects across peripheral immune cell populations and cortical and hippocampal tissues. Peripherally, the combination treatment produced significant reductions in pro-inflammatory myeloid interleukin 6 (IL-6) and tumor necrosis factor (TNF) transcriptexpression, while increasing arginase-1 (ARG1) expression. The combination also enhanced Treg-associated IL-2 receptor alpha (IL-2Ra, also known as CD25), transforming growth factor beta 1 (TGF-b1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)immunomodulatory transcript expression, relative to monotherapies. In the cortical and hippocampal brain regions, the combination significantly reduced pro-inflammatory IL-6 and interleukin 1 beta (IL-1b) expression while increasing CD163 (cluster of differentiation 163) and CD206 (cluster of differentiation 206) transcript expression, markers of M2 macrophages, which are anti-inflammatory cells involved in tissue repair and remodeling. Monotherapy treatments produced limited changes across these endpoints.<\/p>\n

Importantly, GLP-1RA and LD-IL2 treatment was initiated 24 hours after the first LPS administration, demonstrating treatment-associated effects after inflammatory induction had begun.<\/p>\n

In summary, GLP-1RA and LD-IL2 combination treatment produced complementary modulation of immune cell populations and myeloid- and Treg-associated transcripts across peripheral immune cells and CNS tissues. The transcriptional response observed with this combination treatment supports further evaluation and highlights the mechanistic potential of multi-targeted approaches as potential treatments for inflammation-driven neurodegenerative diseases.<\/p>\n

The full paper can be found here<\/a>.<\/p>\n

The study was conducted by Dr. Stanley Appel, Dr. Aaron Thome and other researchers at Houston Methodist Neurological Institute and was funded by Coya through a sponsored research agreement with Houston Methodist Hospital Research Institute.<\/p>\n

About COYA 303<\/strong><\/p>\n

COYA 303 is an investigational proprietary biologic combination of low-dose IL-2 and a glucagon-like-peptide-1 receptor agonist (GLP-1RA) designed for subcutaneous administration. In preclinical studies, COYA 303 has demonstrated a dual immunomodulatory mechanism of action targeting regulatory T cells (Tregs) and pro-inflammatory myeloid cells.<\/p>\n

About Coya Therapeutics, Inc.<\/strong><\/p>\n

Headquartered in Houston, TX, Coya Therapeutics, Inc. (Nasdaq: COYA) is a clinical-stage biotechnology company developing proprietary treatments focused on the biology and potential therapeutic advantages of regulatory T cells (\u201cTregs\u201d) to target systemic inflammation and neuroinflammation. Dysfunctional Tregs underlie numerous conditions, including neurodegenerative, metabolic, and autoimmune diseases. This cellular dysfunction may lead to sustained inflammation and oxidative stress resulting in lack of homeostasis of the immune system.<\/p>\n

Coya\u2019s investigational product candidate pipeline leverages multiple therapeutic modalities aimed at restoring the anti-inflammatory and immunomodulatory functions of Tregs. Coya\u2019s therapeutic platforms include Treg-enhancing biologics, Treg-derived exosomes, and autologous Treg cell therapy.<\/p>\n

For more information about Coya, please visit www.coyatherapeutics.com<\/a><\/p>\n

Forward-Looking Statements<\/strong><\/p>\n

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Statements in this press release that are not statements of historical fact are forward-looking statements. Such forward-looking statements include, without limitation, statements regarding: expectations of Coya Therapeutics, Inc. (the \u201cCompany\u201d) regarding the potential benefits, effectiveness and safety of its product candidates; the Company\u2019s ability to advance its product candidates through the preclinical and clinical development processes; the Company\u2019s plans and ability to advance COYA 303, including its ability to secure non-dilutive funding or a partnership; the Company\u2019s expectations regarding the timing and availability of additional preclinical or clinical data; and the potential therapeutic benefits and economic value of the Company\u2019s product candidates. These forward-looking statements are based on the beliefs of the management of the Company as well as assumptions made by and information currently available to the Company. Such statements reflect the current views of the Company with respect to future events and are subject to known and unknown risks and uncertainties. In light of these risks and uncertainties, the events or circumstances referred to in the forward-looking statements may not occur. These and other factors that may cause the Company\u2019s actual results to differ from current expectations are discussed in the Company\u2019s filings with the Securities and Exchange Commission (the \u201cSEC\u201d), including the section titled \u201cRisk Factors\u201d in the Company\u2019s Annual Report on Form 10-K for the year ended December 31, 2025. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date this press release is given. Except as required by law, the Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20260908230713\/en\/<\/a><\/span><\/p>\n

Investor Contact<\/b>
David Snyder, CFO
david@coyatherapeutics.com<\/a><\/p>\n

Media Contacts<\/b>
Russo Partners<\/b>
David Schull
David.Schull@russopartnersllc.com<\/a>
858-717-2310<\/p>\n

Rachelle Babb
rachelle.babb@russopartnersllc.com<\/a>
929-325-7559<\/p>\n

KEYWORDS:<\/b> Texas United States North America<\/p>\n

INDUSTRY KEYWORDS:<\/b> Science Neurology Other Science Biotechnology Research Pharmaceutical General Health Health<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
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Coya Therapeutics Announces Publication of Preclinical Study Demonstrating Combination Immunomodulatory Effects of COYA 303 in a Well-Established Model of Peripheral and CNS Inflammation Study results showed complementary immunomodulatory effects of COYA 303, a combination of proprietary low-dose IL-2 (LD-IL2) and a GLP-1 Receptor Agonist (GLP-1RA), compared to either LD-IL2 or GLP-1RA as monotherapy GLP-1RA attenuated myeloid expansion and inflammatory transcriptional responses, whereas LD-IL2 increased Treg numbers and transcripts associated with Treg stability and suppressive function Coya believes findings support further evaluation of COYA 303 and combination approaches in addressing Alzheimer\u2019s disease and other complex neurodegenerative indications Coya will continue to pursue non-dilutive avenues and potential partnerships to advance the COYA 303 program HOUSTON–(BUSINESS WIRE)–Coya Therapeutics, Inc. (NASDAQ: COYA) (\u201cCoya\u201d or … <\/p>\n

Continue reading “Coya Therapeutics Announces Publication of Preclinical Study Demonstrating Combination Immunomodulatory Effects of COYA 303 in a Well-Established Model of Peripheral and CNS Inflammation”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1001114","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCoya Therapeutics Announces Publication of Preclinical Study Demonstrating Combination Immunomodulatory Effects of COYA 303 in a Well-Established Model of Peripheral and CNS Inflammation - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/coya-therapeutics-announces-publication-of-preclinical-study-demonstrating-combination-immunomodulatory-effects-of-coya-303-in-a-well-established-model-of-peripheral-and-cns-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Coya Therapeutics Announces Publication of Preclinical Study Demonstrating Combination Immunomodulatory Effects of COYA 303 in a Well-Established Model of Peripheral and CNS Inflammation - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Coya Therapeutics Announces Publication of Preclinical Study Demonstrating Combination Immunomodulatory Effects of COYA 303 in a Well-Established Model of Peripheral and CNS Inflammation Study results showed complementary immunomodulatory effects of COYA 303, a combination of proprietary low-dose IL-2 (LD-IL2) and a GLP-1 Receptor Agonist (GLP-1RA), compared to either LD-IL2 or GLP-1RA as monotherapy GLP-1RA attenuated myeloid expansion and inflammatory transcriptional responses, whereas LD-IL2 increased Treg numbers and transcripts associated with Treg stability and suppressive function Coya believes findings support further evaluation of COYA 303 and combination approaches in addressing Alzheimer\u2019s disease and other complex neurodegenerative indications Coya will continue to pursue non-dilutive avenues and potential partnerships to advance the COYA 303 program HOUSTON–(BUSINESS WIRE)–Coya Therapeutics, Inc. 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