{"id":1000277,"date":"2026-09-03T11:52:45","date_gmt":"2026-09-03T15:52:45","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/nexalin-technology-announces-new-secondary-analysis-of-previously-published-clinical-trial-data-reveals-previously-unreported-improvements-in-memory-comprehension-and-language-function-in-alzhei\/"},"modified":"2026-09-03T11:52:45","modified_gmt":"2026-09-03T15:52:45","slug":"nexalin-technology-announces-new-secondary-analysis-of-previously-published-clinical-trial-data-reveals-previously-unreported-improvements-in-memory-comprehension-and-language-function-in-alzhei","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/nexalin-technology-announces-new-secondary-analysis-of-previously-published-clinical-trial-data-reveals-previously-unreported-improvements-in-memory-comprehension-and-language-function-in-alzhei\/","title":{"rendered":"Nexalin Technology Announces\u00a0New Secondary Analysis of Previously Published Clinical Trial Data Reveals Previously Unreported Improvements in Memory, Comprehension and Language Function in Alzheimer\u2019s Patients; ADAS-Cog Subscale Analysis to Guide Design of Planned U.S. Alzheimer\u2019s Pilot Study"},"content":{"rendered":"
\n

\n Further analysis of ADAS-Cog data from the Company\u2019s randomized, sham-controlled clinical trial \u2014 previously published in the Journal of Alzheimer\u2019s Disease and in Radiology \u2014 identifies specific improvements in cognitive domains associated with memory in Alzheimer\u2019s patients\u00a0<\/em>\n <\/p>\n

\n One half of evaluable active-arm participants achieved a clinically meaningful improvement of four or more points on the ADAS-Cog, with domain-level gains in comprehension, memory and language function still evident three months after treatment ended. The largest individual gains were observed among patients with the greatest cognitive impairment at baseline. <\/em>\n <\/p>\n

\n Findings are expected to directly inform endpoint selection and patient-selection strategy for Nexalin\u2019s planned U.S. pilot study of the Gen-2 SYNC\u2122 console in Alzheimer\u2019s disease, following the Company\u2019s completed Q-Submission meeting with the FDA<\/em>\n <\/p>\n

HOUSTON, Sept. 03, 2026 (GLOBE NEWSWIRE) — Nexalin Technology, Inc. (Nasdaq: NXL) (the \u201cCompany\u201d or \u201cNexalin\u201d), the leader in non-invasive Deep Intracranial Frequency Stimulation (DIFS\u2122) of the brain, today announced the results of an exploratory, item-level analysis of Alzheimer\u2019s Disease Assessment Scale\u2013Cognitive Subscale (ADAS-Cog) data from its completed randomized, double-blind, sham-controlled clinical trial evaluating the Company\u2019s proprietary 15 milliamp (mA) Gen-2 SYNC DIFS\u2122 neurostimulation device in patients with mild Alzheimer\u2019s disease. The analysis was conducted to guide endpoint selection and patient-selection strategy for the Company\u2019s planned U.S. pilot study in Alzheimer\u2019s disease. A deeper dive into the trial\u2019s cognitive subscales revealed improvements in distinct areas of mental function that are not visible in the aggregate composite score.<\/p>\n

Results from the 46-patient trial have been published in two peer-reviewed journals: the Journal of Alzheimer\u2019s Disease (2024) and Radiology (2025). As previously reported, the trial also demonstrated statistically significant improvements versus sham on the Mini-Mental State Examination (MMSE) (P = .001) and the Montreal Cognitive Assessment (MoCA) (P = .03), together with treatment-associated enhancements in functional connectivity between the hippocampus and key cortical regions observed on functional MRI. This secondary analysis examined individual cognitive and functional subscales within the validated assessment ADAS-Cog. While the original publication focused on the predefined primary and secondary endpoints, the additional analysis identified previously unreported improvements across five Alzheimer’s disease-related cognitive domains, with gains still evident three months after treatment concluded. Because meaningful changes within individual cognitive domains can be diluted when combined into a single composite figure, the Company conducted a descriptive, item-level analysis of individual participant data from the active treatment arm to better understand which specific domains responded to treatment, and in which patients. The full Radiology study is available at: https:\/\/pubs.rsna.org\/doi\/10.1148\/radiol.241463<\/a>.<\/p>\n

Among the 20 active-arm participants with complete assessment data, 10 achieved an improvement of four or more points at one or more assessment points \u2014 a threshold widely regarded as clinically meaningful on the ADAS-Cog. The largest individual improvements, of eight points each, were observed in the two participants with the greatest cognitive impairment at baseline, suggesting a potential relationship between baseline disease severity and treatment response. Domain-level review identified improvement patterns concentrated in recognition memory, comprehension of spoken language, spoken language ability, word-finding, and constructional praxis at the three-month follow-up assessment \u2014 three months after the final treatment session.<\/p>\n

The subscale analysis was post-hoc, exploratory, and descriptive in nature. It was not prespecified in the trial protocol, includes a small number of participants, and has not been adjusted for multiple comparisons. Findings from analyses of this kind are hypothesis-generating rather than evidence of treatment efficacy and are intended to inform the design of future controlled clinical studies.<\/p>\n

\u201cThe value of this work is that it tells us where to look next,\u201d said Mark White, Chief Executive Officer of Nexalin Technology. \u201cOur published trial demonstrated significant improvements versus sham on the MMSE and MoCA, with corresponding changes on brain imaging. The item-level ADAS-Cog analysis now gives us a more granular map of the cognitive domains in which responses were concentrated \u2014 and which patients responded most \u2014 and we expect these insights will directly shape endpoint selection and patient-selection strategy as we advance our planned U.S. pilot study with the FDA.\u201d<\/p>\n

\u201cComposite scales such as the ADAS-Cog are essential tools, but they can obscure domain-specific effects, particularly in smaller studies,\u201d said Dr. David Owens, Chief Medical Officer of Nexalin Technology. \u201cExamining the data beneath the composite at the item level is a standard and appropriate way to generate hypotheses for the next stage of clinical development. We expect these observations to help us design a more focused and rigorous study, including how we select patients and define endpoints.\u201d<\/p>\n

The Company expects to incorporate these findings into the protocol design for its planned U.S. pilot study of the Gen-2 SYNC console in Alzheimer\u2019s disease, building on the feedback received in the Company\u2019s Q-Submission meeting with the FDA, announced on December 3, 2025, and the broader FDA strategy outlined in the Company\u2019s April 15, 2026 announcement. The Company intends to provide further updates as its U.S. Alzheimer\u2019s program advances.<\/p>\n

\n About Nexalin Technology, Inc.<\/strong>\n <\/p>\n

Nexalin designs and develops innovative neurostimulation products to uniquely help combat the ongoing global mental health epidemic. Nexalin\u2019s medical devices are non-invasive and undetectable to the human body. Nexalin products are developed to provide relief to those afflicted with mental health issues using frequency based bioelectronic medical technology. Nexalin believes its neurostimulation medical devices can penetrate structures deep in the mid-brain that are associated with mental health disorders. Nexalin believes the deeper-penetrating waveform in its next-generation devices will generate enhanced patient response without any adverse side effects. The Nexalin Gen-2 15 milliamp neurostimulation device has been approved in China, Brazil, Oman and Israel. Additional information about the Company is available at: https:\/\/nexalin.com\/.<\/p>\n

\n FORWARD-LOOKING STATEMENTS<\/strong>\n <\/p>\n

This press release contains \u201cforward-looking statements\u201d within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995 (the \u201cPSLRA\u201d). These forward-looking statements relate to future events, future performance, or management\u2019s current expectations, beliefs, assumptions, plans, estimates, intentions, or projections relating to the future, and are not guarantees of future performance. Any statements that are not statements of historical fact, or that refer to expectations, projections, or other characterizations of future events or circumstances (including, without limitation, statements containing the words \u201cbelieves,\u201d \u201cexpects,\u201d \u201canticipates,\u201d \u201cplans,\u201d \u201cintends,\u201d \u201cwill,\u201d \u201cmay,\u201d \u201ccould,\u201d \u201cshould,\u201d \u201cwould,\u201d \u201cdesigned to,\u201d \u201cpositioned to,\u201d \u201cpotential,\u201d \u201ctargeted,\u201d \u201cseeking,\u201d \u201ccontinues,\u201d \u201cstrategy,\u201d \u201copportunity,\u201d \u201cestimates,\u201d \u201cprojects,\u201d \u201cforecasts,\u201d \u201cpredicts,\u201d \u201coutlook,\u201d \u201cguidance,\u201d or similar expressions, or the negative of such terms), are forward-looking statements. Forward-looking statements are based on Nexalin\u2019s current expectations, assumptions, estimates, projections, and beliefs as of the date hereof. These statements are subject to significant risks, uncertainties, and other factors, many of which are beyond the Company\u2019s control, that could cause actual results, performance, or achievements to differ materially from those expressed or implied by the forward-looking statements. Readers are cautioned not to place undue reliance on any forward-looking statements, which speak only as of the date of this press release.<\/p>\n

Forward-looking statements in this press release include, but are not limited to, statements regarding: the interpretation, validation, and clinical significance of the Company\u2019s clinical trial results and of exploratory analyses of such results, including the ADAS-Cog subscale analysis described herein; the Company\u2019s expectation that the subscale findings will inform or shape endpoint selection and patient-selection strategy for its planned U.S. Alzheimer\u2019s pilot study, and that FDA will accept endpoints or enrollment criteria derived from a post-hoc analysis; the Company\u2019s ability to replicate observations from exploratory analyses in larger, randomized, or controlled clinical studies; the design, enrollment, timing, progress, results, and potential outcomes of the Company\u2019s planned U.S. clinical development program in Alzheimer\u2019s disease, which has not commenced, and of the Company\u2019s separate ongoing HALO\u2122 Clarity pivotal study of the Gen-3 HALO device in insomnia; the mechanism of action, depth of penetration, safety profile, and differentiation of Nexalin\u2019s DIFS\u2122 platform, including the Company\u2019s belief that its next-generation waveform will generate enhanced patient response without adverse side effects; the potential for future development, regulatory progress (including the planned De Novo submission for the Gen-3 HALO device in insomnia), and commercialization of the Company\u2019s products and technology; management\u2019s expectations regarding future regulatory submissions, clearances, and approvals; and the Company\u2019s strategic plans, business prospects, capital needs, and ability to continue as a going concern.<\/p>\n

Forward-looking statements are subject to numerous risks and uncertainties, many of which are beyond the Company\u2019s control. Such risks include, but are not limited to: the inherent limitations of post-hoc, exploratory, and descriptive subscale analyses, which were not prespecified, have not been adjusted for multiple comparisons, are not powered to establish statistical significance, and may reflect practice effects, placebo response, regression to the mean, or chance findings; the risk that the FDA may not agree with the endpoints, responder definitions, enrollment criteria, or statistical approaches derived from this post-hoc subscale analysis, and that any feedback received in a Q-Submission meeting is non-binding and does not constitute FDA agreement with, or endorsement of, the Company\u2019s proposed study design; the risk that the responder and domain-level observations described herein, which were derived from active-arm participants only and without a corresponding sham-arm comparison, may not be attributable to treatment; uncertainties regarding the design, enrollment, execution, timing, results, and completion of clinical trials, including the HALO\u2122 Clarity pivotal program and the Company\u2019s planned U.S. Alzheimer\u2019s program; the risk that the planned U.S. Alzheimer\u2019s pilot study may not be initiated, may be delayed, or may be materially redesigned, including as a result of FDA feedback, IDE or IRB requirements, site or investigator availability, or the Company\u2019s inability to fund the study; the ability to obtain regulatory clearance or approval from the FDA or other regulatory bodies, including with respect to any planned De Novo submission; the sufficiency of clinical and non-clinical data to support regulatory submissions; the potential for adverse events, safety concerns, or product performance issues; uncertainty regarding the mechanism of action, depth of penetration, and the extent to which preliminary signals will translate into clinical benefit in larger, controlled studies; market acceptance of, and reimbursement for, the Company\u2019s products; the Company\u2019s ability to protect and enforce its intellectual property rights; competition from existing and new treatment alternatives; the Company\u2019s reliance on third-party manufacturers, suppliers, and clinical investigators; the Company\u2019s ability to generate international revenue and to commercialize its products in international markets, and to maintain ongoing compliance with applicable foreign post-market requirements; the Company\u2019s ability to secure adequate funding on acceptable terms to complete its planned clinical, regulatory, and commercial programs; ; and general economic, political, regulatory, and market conditions. Additional risks and uncertainties that could cause actual results to differ materially are described under the heading \u201cRisk Factors\u201d in the Company\u2019s most recent Annual Report on Form 10-K for the year ended December 31, 2025, and in the Company\u2019s subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and other filings the Company makes from time to time with the U.S. Securities and Exchange Commission (the \u201cSEC\u201d). Copies of these filings are available free of charge on the SEC\u2019s website at www.sec.gov and on the Company\u2019s investor relations website. New risk factors emerge from time to time, and it is not possible for the Company to predict all such risk factors or to assess the impact of all such risk factors on its business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements.<\/p>\n

All forward-looking statements in this press release are qualified in their entirety by this cautionary statement and the risk factors and other cautionary statements set forth in the Company\u2019s SEC filings referenced above, and speak only as of the date they are made. Except as required by applicable law, the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, changed circumstances, or otherwise, after the date of this press release.<\/p>\n

\n Contact:
<\/strong>Crescendo Communications, LLC
Tel: (212) 671-1020
Email: NXL@crescendo-ir.com<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Further analysis of ADAS-Cog data from the Company\u2019s randomized, sham-controlled clinical trial \u2014 previously published in the Journal of Alzheimer\u2019s Disease and in Radiology \u2014 identifies specific improvements in cognitive domains associated with memory in Alzheimer\u2019s patients\u00a0 One half of evaluable active-arm participants achieved a clinically meaningful improvement of four or more points on the ADAS-Cog, with domain-level gains in comprehension, memory and language function still evident three months after treatment ended. The largest individual gains were observed among patients with the greatest cognitive impairment at baseline. Findings are expected to directly inform endpoint selection and patient-selection strategy for Nexalin\u2019s planned U.S. pilot study of the Gen-2 SYNC\u2122 console in Alzheimer\u2019s disease, following the Company\u2019s completed Q-Submission meeting with the … <\/p>\n

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ADAS-Cog Subscale Analysis to Guide Design of Planned U.S. Alzheimer\u2019s Pilot Study - Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/nexalin-technology-announces-new-secondary-analysis-of-previously-published-clinical-trial-data-reveals-previously-unreported-improvements-in-memory-comprehension-and-language-function-in-alzhei\/","og_locale":"en_US","og_type":"article","og_title":"Nexalin Technology Announces\u00a0New Secondary Analysis of Previously Published Clinical Trial Data Reveals Previously Unreported Improvements in Memory, Comprehension and Language Function in Alzheimer\u2019s Patients; ADAS-Cog Subscale Analysis to Guide Design of Planned U.S. Alzheimer\u2019s Pilot Study - Market Newsdesk","og_description":"Further analysis of ADAS-Cog data from the Company\u2019s randomized, sham-controlled clinical trial \u2014 previously published in the Journal of Alzheimer\u2019s Disease and in Radiology \u2014 identifies specific improvements in cognitive domains associated with memory in Alzheimer\u2019s patients\u00a0 One half of evaluable active-arm participants achieved a clinically meaningful improvement of four or more points on the ADAS-Cog, with domain-level gains in comprehension, memory and language function still evident three months after treatment ended. The largest individual gains were observed among patients with the greatest cognitive impairment at baseline. Findings are expected to directly inform endpoint selection and patient-selection strategy for Nexalin\u2019s planned U.S. pilot study of the Gen-2 SYNC\u2122 console in Alzheimer\u2019s disease, following the Company\u2019s completed Q-Submission meeting with the … Continue reading \"Nexalin Technology Announces\u00a0New Secondary Analysis of Previously Published Clinical Trial Data Reveals Previously Unreported Improvements in Memory, Comprehension and Language Function in Alzheimer\u2019s Patients; ADAS-Cog Subscale Analysis to Guide Design of Planned U.S. Alzheimer\u2019s Pilot Study\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/nexalin-technology-announces-new-secondary-analysis-of-previously-published-clinical-trial-data-reveals-previously-unreported-improvements-in-memory-comprehension-and-language-function-in-alzhei\/","og_site_name":"Market Newsdesk","article_published_time":"2026-09-03T15:52:45+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgyMDU0MyM3ODE1NjUyIzUwMDEwOTExMw==","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"10 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/nexalin-technology-announces-new-secondary-analysis-of-previously-published-clinical-trial-data-reveals-previously-unreported-improvements-in-memory-comprehension-and-language-function-in-alzhei\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/nexalin-technology-announces-new-secondary-analysis-of-previously-published-clinical-trial-data-reveals-previously-unreported-improvements-in-memory-comprehension-and-language-function-in-alzhei\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Nexalin Technology Announces\u00a0New Secondary Analysis of Previously Published Clinical Trial Data Reveals Previously Unreported Improvements in Memory, Comprehension and Language Function in Alzheimer\u2019s Patients; 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